Table 2 significantly enriched KEGG pathways in D vs. ND and DT vs. D

D vs ND

Fatty acid metabolism

55

8

Biosynthesis of secondary metabolites

174

74

Citrate cycle (TCA cycle)

41

7

Carbon metabolism

78

27

Pyruvate metabolism

40

13

Ribosome biogenesis in eukaryotes

0

2

Glycolysis / Gluconeogenesis

44

18

Fatty acid biosynthesis

33

5

Galactose metabolism

27

8

Cardiac muscle contraction

36

0

Biosynthesis of amino acids

60

28

Starch and sucrose metabolism

41

22

Oxidative phosphorylation

64

8

Lysosome

48

9

Carbon fixation in photosynthetic organisms

24

18

beta-Alanine metabolism

22

8

Ribosome

127

36

Carbon fixation pathways in prokaryotes

22

4

Propanoate metabolism

23

0

Fatty acid degradation

28

5

Fructose and mannose metabolism

32

13

Signaling pathways regulating pluripotency of stem cells

0

2

One carbon pool by folate

26

2

Drug metabolism - other enzymes

26

2

Spliceosome

4

14

Meiosis - yeast

1

1

Cell cycle

0

7

Phagosome

34

17

Aminoacyl-tRNA biosynthesis

8

4

Aflatoxin biosynthesis

10

0

Nucleotide excision repair

0

1

Ras signaling pathway

3

1

AMPK signaling pathway

40

10

Epstein-Barr virus infection

4

12

Arginine and proline metabolism

25

9

TD vs D

Cardiac muscle contraction

0

14

Drug metabolism - other enzymes

2

11

Fatty acid metabolism

2

18

Carbon fixation pathways in prokaryotes

0

11

Spliceosome

1

0

Ribosome

3

9

MicroRNAs in cancer

12

6

Citrate cycle (TCA cycle)

1

14

Styrene degradation

0

4

Vitamin digestion and absorption

2

3

Tryptophan metabolism

1

9

Tyrosine metabolism

1

8

Cutin, suberine and wax biosynthesis

1

5

One carbon pool by folate

1

9

Photosynthesis - antenna proteins

0

9

Fatty acid degradation

1

10

Insulin signaling pathway

8

10

Novobiocin biosynthesis

0

2

Adrenergic signaling in cardiomyocytes

0

13