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Fig. 6 | BMC Genomics

Fig. 6

From: Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

Fig. 6

Hypergeometric Analysis of Time Series (HATS) for pairwise comparisons of the transcriptomes in the pfcrt data set. As for the pfmdr1 dataset, we performed HATS analysis by combining FFT to align the time series with a hypergeometric distribution approach based on random permutations to compute an enrichment score for each gene set. Normalization of the enrichment scores was performed using the expression baseline constituted by the background pool of 11 transcriptome data sets. As before, we applied a threshold of normalized gene set rank >0.9 for gene sets we considered positively enriched and normalized gene set rank <0.1 for gene sets considered negatively enriched. The gene sets were built using GO, KEGG, and the Malaria Parasite Metabolic Pathway. a Gene sets that are enriched (left, mean ranking values >0.9) or depleted (right, mean ranking values <0.1) in 7G8 in comparison with 7G8pfcrt_CTL. b Gene sets that are enriched (left, mean ranking values >0.9) or depleted (right, mean ranking values <0.1) in 7G8 in comparison to 7G8pfcrt_T76K. c Venn diagrams depicting overlaps of gene sets significantly enriched (left) or depleted (right) in 7G8 for both 7G8 vs. 7G8pfcrt_CTL and 7G8 vs. 7G8pfcrt_T76K pairwise comparisons

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