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Fig. 3 | BMC Genomics

Fig. 3

From: Chronic binge alcohol administration dysregulates global regulatory gene networks associated with skeletal muscle wasting in simian immunodeficiency virus-infected macaques

Fig. 3

Venn diagram of CBA-dependent alterations in gene regulatory networks at end-stage SIV infection. The majority of differentially expressed genes (521) in the SKM of CBA/SIV macaques (≥1.5-fold different) compared to SKM of SUC/SIV macaques) did not correlate with alterations in miRNA or methylation. However, some of the differentially expressed genes were epigenetically regulated: changes in methylation status (24 genes), miRNA expression (1 gene), or both together (1 gene) were inversely proportional to the observed CBA-dependent changes in mRNA gene expression. Further, there were CBA-dependent miRNA (163 target genes) and methylation (143 genes) alterations that were not found in the mRNA data that potentially contribute to skeletal muscle wasting

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