Fig. 4

Schematic integrating the global effects of CBA on gene regulatory networks important for normal muscle function at end-stage SIV infection. Normal muscle function requires functional muscle fibers and the ability to activate satellite cells to proliferate and differentiate and pre-synaptic neurons to form functional neuromuscular junctions. The blue ovals indicate the cell type or physiological function necessary for normal muscle function and integrity. The orange octagons indicate the general biological functions required to maintain the function and/or integrity of the cell type or physiological function. The yellow boxes indicate the specific biological functions affected by CBA-dependent changes in gene regulatory networks. The number of mRNA (genes), microRNA (miRs), or methylation (Me) that are altered due to CBA are indicated for each specific biological function