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Table 1 CBA-dependent alterations in microRNA expression at end-stage SIV infection

From: Chronic binge alcohol administration dysregulates global regulatory gene networks associated with skeletal muscle wasting in simian immunodeficiency virus-infected macaques

Category

Term

Total genes in term

Union targets in term

miRNAs in term

Score

Reactome

Axon_guidance

266

154

28

3.983

Reactome

Developmental_biology

494

229

28

3.716

KEGG

Pathways_in_cancer

325

173

28

2.951

Reactome

L1cam_interactions

94

61

26

2.77

KEGG

Mapk_signaling_pathway

272

135

29

2.466

KEGG

Wnt_signaling_pathway

150

91

28

2.466

Go_mf

Protein_binding_transcription_factor_activity

369

164

28

2.334

Reactome

Signalling_by_ngf

221

118

26

2.243

PID

Direct_p53_effectors

137

65

27

2.062

KEGG

Focal_adhesion

199

99

27

1.992

Reactome

Hemostasis

467

191

29

1.989

KEGG

Endocytosis

201

102

27

1.944

KEGG

Prostate_cancer

89

49

26

1.941

KEGG

Neurotrophin_signaling_pathway

127

71

27

1.909

PID

Pdgfr-beta_signaling_pathway

126

69

27

1.9

PID

Regulation_of_nuclear_smad2_3_signaling

82

52

27

1.847

Reactome

Neuronal_system

289

120

28

1.837

KEGG

Glioma

65

35

27

1.836

PID

Signaling_events_mediated_by_hepatocyte_growth_factor_receptor_(c-met)

77

50

26

1.74

KEGG

Regulation_of_actin_cytoskeleton

213

100

26

1.73

PID

E2f_transcription_factor_network

73

44

25

1.717

Reactome

Transmission_across_chemical_synapses

190

85

28

1.701

PID

C-myb_transcription_factor_network

81

46

24

1.683

Reactome

Nuclear_receptor_transcription_pathway

51

27

26

1.66

PID

Ephb_forward_signaling

36

27

22

1.619

KEGG

Erbb_signaling_pathway

87

48

27

1.614

KEGG

Melanoma

71

34

27

1.594

KEGG

Melanogenesis

101

55

28

1.582

KEGG

Small_cell_lung_cancer

84

43

26

1.563

PID

Notch_signaling_pathway

59

37

25

1.55

KEGG

Tgf-beta_signaling_pathway

84

47

27

1.545

PID

Tcr_signaling_in_naive_cd4 + _t_cells

64

36

24

1.544

Reactome

Signaling_by_egfr

109

62

25

1.521

KEGG

Pancreatic_cancer

70

41

26

1.518

KEGG

Fc_gamma_r-mediated_phagocytosis

94

47

25

1.506

PID

Coregulation_of_androgen_receptor_activity

57

35

26

1.5

KEGG

Adherens_junction

73

44

26

1.499

KEGG

Tight_junction

132

61

27

1.498

PID

Shp2_signaling

54

34

25

1.485

PID

P73_transcription_factor_network

73

34

25

1.462

Reactome

Rho_gtpase_cycle

124

58

25

1.455

Reactome

Signaling_by_fgfr

114

57

26

1.447

KEGG

Chronic_myeloid_leukemia

73

39

25

1.432

KEGG

Renal_cell_carcinoma

70

40

25

1.428

PID

Ap-1_transcription_factor_network

69

41

25

1.41

Reactome

G1_phase

38

23

22

1.387

KEGG

Dilated_cardiomyopathy

90

42

24

1.384

Reactome

Signaling_by_interleukins

106

47

25

1.371

Reactome

Downstream_signal_transduction

93

53

25

1.354

KEGG

Bacterial_invasion_of_epithelial_cells

70

39

24

1.349

Reactome

Adaptive_immune_system

482

162

28

1.347

PID

Integrins_in_angiogenesis

74

46

25

1.342

KEGG

Ubiquitin_mediated_proteolysis

135

70

24

1.337

PID

Hif-1-alpha_transcription_factor_network

65

35

26

1.337

KEGG

Oocyte_meiosis

112

52

27

1.334

PID

Cxcr4-mediated_signaling_events

102

54

25

1.323

Reactome

Cd28_co-stimulation

31

20

21

1.316

PID

Role_of_calcineurin-dependent_nfat_signaling_in_lymphocytes

55

35

23

1.31

KEGG

Cell_cycle

124

55

25

1.29

PID

Cdc42_signaling_events

70

40

25

1.29

KEGG

P53_signaling_pathway

68

38

24

1.289

PID

Posttranslational_regulation_of_adherens_junction_stability_and_dissassembly

48

29

24

1.28

Reactome

Platelet_activation_signaling_and_aggregation

205

85

27

1.278

PID

Regulation_of_retinoblastoma_protein

64

35

27

1.275

PID

Bcr_signaling_pathway

68

36

25

1.274

PID

Signaling_events_regulated_by_ret_tyrosine_kinase

38

22

22

1.266

Reactome

Circadian_clock

33

20

24

1.254

KEGG

Long-term_potentiation

70

40

25

1.252

Reactome

Cytokine_signaling_in_immune_system

220

77

27

1.236

KEGG

Shigellosis

61

36

23

1.233

KEGG

Vascular_smooth_muscle_contraction

126

49

26

1.21

KEGG

Gnrh_signaling_pathway

101

45

27

1.21

Reactome

Mitotic_g1-g1_s_phases

135

46

25

1.195

PID

Signaling_events_mediated_by_hdac_class_i

67

31

22

1.183

PID

Foxo_family_signaling

49

31

25

1.179

PID

Signaling_events_mediated_by_VEGFR

68

41

24

1.163

KEGG

Insulin_signaling_pathway

137

63

28

1.153

PID

Igf1_pathway

29

21

23

1.147

Reactome

Cell_cycle_mitotic

330

95

27

1.146

PID

Validated_targets_of_c-myc_transcriptional_repression

63

31

25

1.137

Reactome

P75_ntr_receptor-mediated_signalling

86

40

23

1.135

KEGG

Colorectal_cancer

62

38

25

1.13

Reactome

Cell_death_signalling_via_nrage_nrif_and_nade

64

32

23

1.126

Reactome

Transmembrane_transport_of_small_molecules

427

145

28

1.125

PID

Atf-2_transcription_factor_network

58

34

25

1.124

PID

Ifn-gamma_pathway

42

30

24

1.12

Reactome

Metabolism_of_liPIDs_and_lipoproteins

292

89

27

1.119

KEGG

Calcium_signaling_pathway

177

73

26

1.113

Reactome

G_alpha_(12_13)_signalling_events

77

36

22

1.111

PID

Syndecan-1-mediated_signaling_events

46

27

22

1.11

PID

Lpa_receptor_mediated_events

66

37

23

1.109

Reactome

Fatty_acid_triacylglycerol_and_ketone_body_metabolism

112

40

21

1.096

PID

E-cadherin signaling in_the_nascent_adherens_junction

38

27

22

1.094

PID

Bmp_receptor_signaling

42

28

21

1.09

KEGG

Chemokine_signaling_pathway

189

77

28

1.088

Reactome

Nrage_signals_death_through_jnk

47

25

23

1.086

Reactome

Cell-cell_communication

129

60

25

1.083

KEGG

T_cell_receptor_signaling_pathway

108

50

25

1.083

Reactome

Antigen_processing_ubiquitination_proteasome_degradation

213

86

26

1.078

PID

Fgf_signaling_pathway

59

35

24

1.061