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Table 1 CBA-dependent alterations in microRNA expression at end-stage SIV infection

From: Chronic binge alcohol administration dysregulates global regulatory gene networks associated with skeletal muscle wasting in simian immunodeficiency virus-infected macaques

Category Term Total genes in term Union targets in term miRNAs in term Score
Reactome Axon_guidance 266 154 28 3.983
Reactome Developmental_biology 494 229 28 3.716
KEGG Pathways_in_cancer 325 173 28 2.951
Reactome L1cam_interactions 94 61 26 2.77
KEGG Mapk_signaling_pathway 272 135 29 2.466
KEGG Wnt_signaling_pathway 150 91 28 2.466
Go_mf Protein_binding_transcription_factor_activity 369 164 28 2.334
Reactome Signalling_by_ngf 221 118 26 2.243
PID Direct_p53_effectors 137 65 27 2.062
KEGG Focal_adhesion 199 99 27 1.992
Reactome Hemostasis 467 191 29 1.989
KEGG Endocytosis 201 102 27 1.944
KEGG Prostate_cancer 89 49 26 1.941
KEGG Neurotrophin_signaling_pathway 127 71 27 1.909
PID Pdgfr-beta_signaling_pathway 126 69 27 1.9
PID Regulation_of_nuclear_smad2_3_signaling 82 52 27 1.847
Reactome Neuronal_system 289 120 28 1.837
KEGG Glioma 65 35 27 1.836
PID Signaling_events_mediated_by_hepatocyte_growth_factor_receptor_(c-met) 77 50 26 1.74
KEGG Regulation_of_actin_cytoskeleton 213 100 26 1.73
PID E2f_transcription_factor_network 73 44 25 1.717
Reactome Transmission_across_chemical_synapses 190 85 28 1.701
PID C-myb_transcription_factor_network 81 46 24 1.683
Reactome Nuclear_receptor_transcription_pathway 51 27 26 1.66
PID Ephb_forward_signaling 36 27 22 1.619
KEGG Erbb_signaling_pathway 87 48 27 1.614
KEGG Melanoma 71 34 27 1.594
KEGG Melanogenesis 101 55 28 1.582
KEGG Small_cell_lung_cancer 84 43 26 1.563
PID Notch_signaling_pathway 59 37 25 1.55
KEGG Tgf-beta_signaling_pathway 84 47 27 1.545
PID Tcr_signaling_in_naive_cd4 + _t_cells 64 36 24 1.544
Reactome Signaling_by_egfr 109 62 25 1.521
KEGG Pancreatic_cancer 70 41 26 1.518
KEGG Fc_gamma_r-mediated_phagocytosis 94 47 25 1.506
PID Coregulation_of_androgen_receptor_activity 57 35 26 1.5
KEGG Adherens_junction 73 44 26 1.499
KEGG Tight_junction 132 61 27 1.498
PID Shp2_signaling 54 34 25 1.485
PID P73_transcription_factor_network 73 34 25 1.462
Reactome Rho_gtpase_cycle 124 58 25 1.455
Reactome Signaling_by_fgfr 114 57 26 1.447
KEGG Chronic_myeloid_leukemia 73 39 25 1.432
KEGG Renal_cell_carcinoma 70 40 25 1.428
PID Ap-1_transcription_factor_network 69 41 25 1.41
Reactome G1_phase 38 23 22 1.387
KEGG Dilated_cardiomyopathy 90 42 24 1.384
Reactome Signaling_by_interleukins 106 47 25 1.371
Reactome Downstream_signal_transduction 93 53 25 1.354
KEGG Bacterial_invasion_of_epithelial_cells 70 39 24 1.349
Reactome Adaptive_immune_system 482 162 28 1.347
PID Integrins_in_angiogenesis 74 46 25 1.342
KEGG Ubiquitin_mediated_proteolysis 135 70 24 1.337
PID Hif-1-alpha_transcription_factor_network 65 35 26 1.337
KEGG Oocyte_meiosis 112 52 27 1.334
PID Cxcr4-mediated_signaling_events 102 54 25 1.323
Reactome Cd28_co-stimulation 31 20 21 1.316
PID Role_of_calcineurin-dependent_nfat_signaling_in_lymphocytes 55 35 23 1.31
KEGG Cell_cycle 124 55 25 1.29
PID Cdc42_signaling_events 70 40 25 1.29
KEGG P53_signaling_pathway 68 38 24 1.289
PID Posttranslational_regulation_of_adherens_junction_stability_and_dissassembly 48 29 24 1.28
Reactome Platelet_activation_signaling_and_aggregation 205 85 27 1.278
PID Regulation_of_retinoblastoma_protein 64 35 27 1.275
PID Bcr_signaling_pathway 68 36 25 1.274
PID Signaling_events_regulated_by_ret_tyrosine_kinase 38 22 22 1.266
Reactome Circadian_clock 33 20 24 1.254
KEGG Long-term_potentiation 70 40 25 1.252
Reactome Cytokine_signaling_in_immune_system 220 77 27 1.236
KEGG Shigellosis 61 36 23 1.233
KEGG Vascular_smooth_muscle_contraction 126 49 26 1.21
KEGG Gnrh_signaling_pathway 101 45 27 1.21
Reactome Mitotic_g1-g1_s_phases 135 46 25 1.195
PID Signaling_events_mediated_by_hdac_class_i 67 31 22 1.183
PID Foxo_family_signaling 49 31 25 1.179
PID Signaling_events_mediated_by_VEGFR 68 41 24 1.163
KEGG Insulin_signaling_pathway 137 63 28 1.153
PID Igf1_pathway 29 21 23 1.147
Reactome Cell_cycle_mitotic 330 95 27 1.146
PID Validated_targets_of_c-myc_transcriptional_repression 63 31 25 1.137
Reactome P75_ntr_receptor-mediated_signalling 86 40 23 1.135
KEGG Colorectal_cancer 62 38 25 1.13
Reactome Cell_death_signalling_via_nrage_nrif_and_nade 64 32 23 1.126
Reactome Transmembrane_transport_of_small_molecules 427 145 28 1.125
PID Atf-2_transcription_factor_network 58 34 25 1.124
PID Ifn-gamma_pathway 42 30 24 1.12
Reactome Metabolism_of_liPIDs_and_lipoproteins 292 89 27 1.119
KEGG Calcium_signaling_pathway 177 73 26 1.113
Reactome G_alpha_(12_13)_signalling_events 77 36 22 1.111
PID Syndecan-1-mediated_signaling_events 46 27 22 1.11
PID Lpa_receptor_mediated_events 66 37 23 1.109
Reactome Fatty_acid_triacylglycerol_and_ketone_body_metabolism 112 40 21 1.096
PID E-cadherin signaling in_the_nascent_adherens_junction 38 27 22 1.094
PID Bmp_receptor_signaling 42 28 21 1.09
KEGG Chemokine_signaling_pathway 189 77 28 1.088
Reactome Nrage_signals_death_through_jnk 47 25 23 1.086
Reactome Cell-cell_communication 129 60 25 1.083
KEGG T_cell_receptor_signaling_pathway 108 50 25 1.083
Reactome Antigen_processing_ubiquitination_proteasome_degradation 213 86 26 1.078
PID Fgf_signaling_pathway 59 35 24 1.061