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Table 5 Enrichment of GO biological processes in host subnetworks

From: Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors

Category

Term

Size

p-value

ID

Description

N C

N M

pGO

pRp

pRn

Cellular regulation

GO:0045944

Positive regulation of transcription from RNA polymerase II promoter

7

4

6.4∙10-3

1.0∙10-4

1.5∙10-4

GO:0045892

Negative regulation of transcription, DNA-dependent

11

6

0.0

0.0

1.3∙10-4

GO:0051090

Regulation of sequence-specific DNA binding transcription factor activity

6

4

1.1∙10-3

0.0

1.1∙10-4

GO:0051345

Positive regulation of hydrolase activity

8

5

4.0∙10-4

0.0

7.7∙10-5

GO:0051726

Regulation of cell cycle

9

4

6.0∙10-4

7.0∙10-4

1.1∙10-3

Cellular signaling

GO:0023052

Signaling

22

8

9.2∙10-3

0.0

1.1∙10-3

GO:0007166

Cell surface receptor signaling pathway

15

5

3.4∙10-3

6.0∙10-4

1.8∙10-3

Cellular response

GO:0070887

Cellular response to chemical stimulus

17

7

0.0

0.0

4.0∙10-4

GO:0006950

Response to stress

18

10

4.0∙10-3

0.0

4.5∙10-4

GO:0010033

Response to organic substance

17

8

0.0

0.0

4.6∙10-4

Protein modification

GO:0016567

Protein ubiquitination

9

4

0.0

1.0∙10-4

2.9∙10-5

GO:0016310

Phosphorylation

10

5

9.7∙10-3

2.0∙10-4

1.1∙10-4

  1. N C, number of proteins in the largest connected component annotated with a given term; N M, number of proteins in the largest interaction module for a given term; pGO, probability of the same number of proteins as N C being annotated with a given GO term solely through a random selection; pRn, probability that a given number of proteins as N M are annotated with a given GO term solely through random selection in a random network that has the same degree distribution as the human network; pRp, probability that a given number of proteins as N M are annotated with a given GO term solely through random selection. This table contains only the largest statistically significant interaction module for each term; the complete list is available as supplementary information (Additional file 8: Table S6).