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Fig. 5 | BMC Genomics

Fig. 5

From: Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment

Fig. 5

Comparison between natural variation and profiling result. The relationship between RF index max for individual amino acid substitutions and the occurrence frequency in natural circulating strains is shown. This comparison was performed on both M1 and M2 proteins with seasonal influenza virus strains (Seasonal flu) and 2009 pandemic swine influenza virus strains (Pandemic flu) being analyzed independently. The grey dashed line represents the cutoff for classifying mutations as deleterious

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