IL-10 and integrin signaling pathways are associated with head and neck cancer progression

BMC Genomics

Table 3 Pathways enriched for DE genes (Progressor vs NonProgressor) with CTCF Binding Sites

Pathway (Source)	FDR adjusted P-value	Gene Members
Beta3 integrin Cell Surface Interactions (PID)	0.00524	FGG, FGB, VTN ^a
P130Cas linkage to MAPK signaling for Integrins (Reactome)	0.0107	FGG, FGB, VTN ^a
Response to Elevated Platelet Cytosolic CA2+ (Reactome)	0.0107	FGG, FGB, ALB
Fibrinolysis Pathway (Biocarta)	0.0107	FGG, FGB

Bold indicates genes found mutated only in the Progressor cohort
FDR false discovery rate
^aSame genes also enriched in Urokinase-type Plasminogen activator (uPA) and UPAR-mediated signaling (PID, FDR adjusted P-value = 0.00524); Beta1 integrin Cell Surface Interactions (PID, FDR adjusted P-value = 0.0107); Integrin Cell Surface Interactions (Reactome, FDR adjusted P-value = 0.0107)

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