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Fig. 2 | BMC Genomics

Fig. 2

From: Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

Fig. 2

Detecting genes with different expression modalities. a The log2 expression density distribution of LDOC1 across 811 CCLE cell lines. LDOC1 has a strong on/off state typical of tumour suppressor genes in homogeneous cell populations. Additionally LDOC1 has been linked as a regulator to NF-KB which in turn promotes the epithelial-mesenchymal transition. b The log2 expression density distribution of LDOC1 across 101 TCGA lung adenocarcinoma patients. LDOC1 has a diluted, non-normal profile - a reflection of the heterogeneity of the tumour tissue. BiSEp can still detect this diluted profile in tumour data. c The log2 expression density distribution of PARP3 across 811 CCLE cell lines

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