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Table 1 Neuropeptides, peptide hormones and receptors affected by diapause

From: Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

Neuropeptide and/or GPCRa

Expressionb

CG number

Log FC

Adipokinetic hormone (AKH)

Corpora cardiaca

CG1171

4.4

AKH receptor (AKHR)

Fat body, spermatheca

CG11325

1.4

Allatostatin A (Ast-A)

CNS, midgut

CG13633

1.9

Allatostatin B (Ast-B or MIPc)

CNS

CG6456

1.1

Allatostatin C (Ast-C)

CNS, midgut

CG14919

1.7

CAPA receptor (capaR)

Renal tubules

CG14575

1.3

CCHamide 2

Midgut, fat body

CG14375

2.1

Corazonin (CRZ)

CNS

CG3302

1.3

CRZ receptor (CrzR)

Fat body, heart

CG10698

2.0

DH31 receptor 1 (DH31–R1)

CNS, gut, renal tubules

CG32843

2.3

Diuretic hormone 44 (DH44)

CNS

CG8348

3.4

DH44 receptor 2 (DH44–R2)

CNS, gut, renal tubules

CG12370

2.5

Insulin-like peptide 2 (DILP2)

Brain

CG8167

1.9

DILP5

Brain, ovary

CG33273

3.2

DILP6

Fat body

CG14049

1.2

DILP8

Ovary

CG14059

−2.6

DLGR1d

Hindgut, salivary gland

CG7665

3.1

Dromyosuppressin (DMS)

Brain, heart

CG6440

1.5

Drosulfakinin (DSK)

Brain

CG18090

1.4

Ion transport peptide (ITP)

CNS, PNS

CG13586

1.2

ITG (Apis-ITG-like)

CNS

CG8216

3.0

Leucokinin (LK)

CNS

CG13480

2.1

LK receptor (LK-R)

CNS, renal tubules

CG10626

1.3

Neuropeptide F receptor (NPFR)

CNS, renal tubules

CG1147

2.4

NPLP1e

CNS

CG3441

2.4

NPLP3

Head, carcass

CG13061

2.1

NPLP4

Fat body (larva), Eye

CG15361

1.3

Orcokinin

CNS, gut

CG13565

1.6

Proctolin

CNS

CG7105

2.2

PTTHf

CNS, Renal tubules?

CG13687

1.1

Short neuropeptide F (sNPF)

CNS

CG13968

1.5

Tachykinin (DTK)

CNS, midgut

CG14734

2.5

Torsog

Ovary

CG1389

−3.3

  1. Notes: The transcripts are sorted alphabetically (significantly >2 fold up- or downregulated; LogFC >1)
  2. aAcronyms used are those for the proteins/peptides
  3. bBased on FlyAtlas and/or modENCODE [116, 117], as well as research papers (summarized in [115]). Expression data are for adult flies, except NPLP4, where expression is most prominent in larvae
  4. cMIP, myoinhibitory peptide
  5. dLeucine-rich repeat-containing G protein-coupled receptor 1. Ligand is the dimeric GPA2/GPB5 protein
  6. eNeuropeptide-like precursor 1
  7. fProthoracicotropic hormone
  8. gReceptor tyrosine kinase, can be activated by PTTH [132]