Table 1 Identification of molecular drivers of gene expression patterns in HRV-induced HBE cells
Upstream regulator | Predicted activation state | Activation Z-score | P-value of overlap |
|---|---|---|---|
IFNG | Activated | 10.890 | 1.08E-90 |
IFNA2 | Activated | 8.106 | 9.79E-85 |
IRF7 | Activated | 8.284 | 1.76E-71 |
TNF | Activated | 9.828 | 3.92E-67 |
IFNL1 | Activated | 6.936 | 1.02E-62 |
IFNAR | Activated | 6.306 | 5.99E-55 |
STAT1 | Activated | 6.317 | 2.32E-54 |
IFNB1 | Activated | 5.436 | 3.64E-50 |
STAT3 | Activated | 4.185 | 9.25E-48 |
IRF1 | Activated | 5.780 | 6.24E-46 |
NFkB (complex) | Activated | 6.850 | 1.41E-39 |
TLR3 | Activated | 5.327 | 5.45E-39 |
IL1B | Activated | 6.926 | 1.29E-37 |
CD40LG | Activated | 4.739 | 8.56E-35 |
OSM | Activated | 5.463 | 1.99E-34 |
TLR4 | Activated | 5.165 | 3.64E-33 |
NKX2-3 | Inhibited | −7.703 | 1.50E-58 |
MAPK1 | Inhibited | −6.867 | 5.29E-58 |
TRIM24 | Inhibited | −6.002 | 1.67E-44 |
IL1RN | Inhibited | −6.336 | 2.84E-35 |