Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Wang, Rong-Lin; Biales, Adam D.; Garcia-Reyero, Natalia; Perkins, Edward J.; Villeneuve, Daniel L.; Ankley, Gerald T.; Bencic, David C.

doi:10.1186/s12864-016-2406-y

Table 2 A summary of 3516 microarray samples and their chemical treatment conditions

From: Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Zebrafish microarray design, sample size, and chemicals	Fathead minnow microarray design, sample size, and chemicals
ZF 21K (Agilent 013223, 15064): USEPA (290)	FHM 15K (Agilent 019597,_036574): USEPA (580)
ethniyl estradiol (EE2)^a	bifenthrin (BIF)^a
fadrozol (FAD)^a	cypermethrin (CYP)^a
fipronil (FIP)^a	permethrin (PER)^a
flutamide (FLU)^a	esfenvalerate (ESF)
ketochonazole (KET)^a	EE2^a
muscimol (MUS)^a	Terbufos (TER)^a
prochloraz (PRO)^a
trenbolone (TRB)^a	FHM 15K (Agilent 019597): USACE (1711)
trilostane (TRI)^a	BPA
vinclozolin (VIN)^a	FAD^a
	FLU^a
ZF 21K (Agilent 013223, 15064): NCBI (154)	Gemfibrozil (GEM)^a
tert-Butylhydroquinone (TBHQ)^a	KET^a
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)^a	KET_TNT_KET
oxygen (O2)^a	KET_TNT_TNT
2,4-dinitrophenol (DNP)	PRO
1,4-dimethoxybenzene (DMB)	RDX
azinphos-methyl (APM)^a	Effluent of Western Lake Superior Sanitary District (WLSSD)
Haloperidol (HAL)	TRB ^a
	TRB_BPA_TRB_BPA
ZF 43K (Agilent 019161): USEPA (24)	TRB_BPA_BPA
FLU^a	TRB_BPA_TRB
PRO^a	TRB_EE2_EE2
	TRB_EE2_TRB
ZF 43K (Agilent 019161): NCBI (270)	TRB_EE2_TRB_EE2
benz(a)anthracene (BAA)^a	TRB_TCC_TCC (triclocarban)
decabromodiphenyl ether (BDE)^a	TRB_TCC_TRB
bisphenol A (BPA)^a	TRB_TCC_TRB_TCC
dibenzothiophene (DBT)	TRI^a
Diazepam (DIA)^a	VIN^a
17ß-estradiol (E2)^a
E2 ^a	FHM 15K (Agilent 019597_036574): NCBI (487)
EE2^a	Diethylstilbestrol (DES)^a
FLU	Dihydrotestosterone (DHT)
genistein (GEN)^a	E2^a
Linuron (LIN)^a	Field exposure (EFFLa, EFFHa^a; effluent, WWTP San Diego; EFFHb^a; effluent, WWTP Los Angeles)
methylparaben (MPA)^a	Field exposure (surface, stream, waste water^a)
protein kinase C inhibitor 412 (PKC412)^a	Field exposure (liver: ElyUS^a, ElyEFF^a, ElyDS^a, HutUS, HutEFF^a, HutDS^a, RochUS^a, RochEFF^a, RochDS^a))
Propanil (PPL)^a	Field exposure (ovary: ELYeff, ELYds, HUTeff, HUTds, ROCHds, ROCHeff)
PRO^a	FLU
Pyrene (PYR)	Linuron
cyclotrimethylenetrinitramine (RDX)^a	perflorinated chemicals (PFC)
	Phenanthrene (PHE)^a
	Progesterone (PGST)
	Propranolol (PPLL)
	RDX

Zebrafish: ZF 21K (Agilent 013223, 21495 probes unique; Agilent 015064, 21495 probes), ZF 43K (Agilent 019161, 43603 probes unique). Fathead minnow: FHM 15K (Agilent 019597, 15208 unique probes; Agilent 036574, 15208 of 49849 unique probes). Chemicals with at least one experiment condition (different exposure durations either in single or combinations) with DEGs ≥ 4 are marked by “^a”, and those shared across platforms or species are highlighted once in bold

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ISSN: 1471-2164

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