Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Table 3 Summary of Cmap by the percentage of query signatures producing informative connections

Microarray platforms	ZF 21K	ZF 43K	FHM 15K
ZF 21K	35/36 (97 %)	11/13 (85 %)	4/8 (50 %)
ZF 43K	6/12 (50 %)	36/36 (100 %)	5/10 (50 %)
FHM 15K	6/12 (50 %)	5/6 (83 %)	35/46 (76 %)

An informative connection was established when a query signature shared the same or similar class of chemicals with at least one of the top five ROGL hits, as ranked by an adjusted connectivity score with a p-value ≤ 1/(S sets of ROGLs). All cross-platform/species Cmap were based on target probe IDs + source gene log-fold changes on shared chemical conditions. Only unique query signatures were considered in calculations

ISSN: 1471-2164