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Table 4 Top five significant hits, if any, of selected Cmap queries within microarray platforms

From: Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Signatures 1st match 2nd match 3rd match 4th match 5th match
  Within ZF 21K (p-value cutoff 1/45 = 0.022)
EE2_30ngL_Ovary_96hr Self FAD_Ovary TRB_F_Brain EE2_Testis FAD_M_Brain
EE2_30ngL_M_Brain_48hr Self EE2_Testis FAD_M_Brain TRB_F_Brain EE2_Ovary
EE2_30ngL_M_Liver_48hr Self TRB_F_Liver EE2_Testis O2_Testis KET_M_Liver
EE2_30ngL_Testis_48hr Self EE2_Ovary EE2_M_Brain FIP_F_Brain TRI_TestisLow
FAD_25ugL_F_Brain_48hr Self TRB_F_Brain FAD_M_Brain FAD_Ovary EE2_Testis
FAD_25ugL_Ovary_96hr Self EE2_Ovary FAD_M_Brain TRI_TestisLow TRB_F_Brain
FIP_5ugL_Testis_48hr Self FIP_Ovary TRI_Testis FIP_M_Brain FLU_Testis
FLU_1700ugL_Ovary_48hr Self FLU_Testis PRO_Testis VIN_Ovary KET_Ovary
MUS_500ugL_F_Brain_48hr Self VIN_Ovary MUS_M_Brain KET_M_Brain VIN_Testis
MUS_500ugL_M_Brain_48hr Self MUS_F_Brain VIN_Ovary KET_M_Brain KET_Ovary
O2_1mgL_Testis_4d Self O2_Ovary EE2_M_Liver O2_Ovary VIN_Testis
PRO_500ugL_F_Brain_48hr FLU_Testis self PRO_Testis VIN_Ovary KET_Ovary
PRO_500ugL_Ovary_48hr Self FLU_Ovary FLU_Testis KET_Ovary PRO_Testis
TCDD_2nM_Embryo_6h Self TCDD_Embryo TRI_Ovary O2_Ovary PRO_Testis
TRI_2500ugL_Testis_24hr Self VIN_Testis VIN_Ovary KET_Ovary TRI_TestisLow
VIN_1000ugL_Ovary_48hr Self KET_Ovary TRI_Testis VIN_Testis FIP_Ovary
VIN_1000ugL_Testis_48hr Self FLU_Testis PRO_Testis TRI_Testis VIN_Ovary
  Within ZF 43K (p-value cutoff 1/39 = 0.026)
BPA_0.01ugL_Ovary_96hr Self BPA_Ovary BPA_Ovary BPA_Ovary BPA_Embryo
E2_1uM_Embryo_4dpf self E2_M_Liver GEN_Embryo GEN_Embryo FLU_Embryo
EE2_0.65mgL_Embryo_48hr EE2_Embryo EE2_Embryo GEN_Embryo PARAB_Embryo PYR_Embryo
E2_5ugL_M_Liver_48hrs self E2_Embryo PARAB_Embryo PARAB_Embryo GEN_Embryo
GEN_2.4mgL_Embryo_48hr self GEN_Embryo PARAB_Embryo DBT_Embryo diazepam_Brain
PKC412_40ugL_fish_6dpf PKC412_fish self RDX_fry diazepam_Brain RDX_fry
PRO_500ugL_F_Brain_48hr PRO_Ovary linuron_Embryo FLU_Ovary PRO_F_Brain linuron_Embryo
PRO_500ugL_Ovary_48hr self FLU_Ovary linuron_Embryo PRO_F_Brain linuron_Embryo
RDX_7.5mgL_fry_96hr self RDX_fry RDX_fry RDX_fry RDX_fry
BPA_8mgL_Embryo_48hr self BPA_Embryo EE2_Embryo BAA_Embryo PRO_Embryo
diazepam_273ngL_brain_14d self diazepam_Brain PKC412_fish RDX_fry RDX_fry
linuron_1.2mgL_Embryo_48hr self linuron_Embryo PKC412_fish BPA_Embryo diazepam_Brain
PARAB_19.8mgL_Embryo_48hr self PARAB_Embryo linuron_Embryo linuron_Embryo PYR_Embryo
PRO_1.7mgL_Embryo_48hr self PRO_Embryo E2_Embryo BPA_Embryo PARAB_Embryo
  Within FHM 15K (p-value cutoff 1/132 = 0.0076)
BIF_0.15ugL_Larvae_48hr BIF_Larvae self TER_M_Brain Mixture_M_Brain KETTNTKET_Ovary
BIF_0.3ugL_Larvae_48hr self CYP_Larvae ESF_Larvae ESF_Larvae PER_Larvae
CYP_1ugL_Larvae_48hr self VZ_Ovary PER_Larvae CYP_larva RDX_Ovary
DES_1ngL_Liver_96h EE2_Liver self PHE_High_Liver E2_X_M_Liver DES_Liver
E2_4ugL_M_Liver_14d self E2_M_Liver EE2_Liver DES_Liver ElyEFF_Liver
EE2_25ngL_Liver_72h E2_M_Liver self E2_X_M_Liver DES_Liver ElyEFF_Liver
GEM_600ugL_Ovary_8d self GEM_Ovary TrbEE2TrbEE2_Ovary RochDS_Ovary TrbEE2TRB_Ovary
PHE_High_Liver_48hr self PHE_Med_Liver ElyEFF_Liver ElyUS_Liver PFCs_Low_Liver
TRB_30ngL_Ovary_24h self FLU_Ovary TrbTCCTCC_Ovary GEM_Ovary GEM_Ovary
TER_57.5ugL_M_Brain_72h self Mixture_M_Brain PER_M_Brain BIF_Larvae KET_Ovary
  1. Only signatures connected to multiple conditions are included. Where similar signatures exist for a condition, only one is listed. ROGL hits are ranked by their adjusted connectivity scores and filtered by a p-value cutoff of 1/(number of sets of ROGLs). Informative connections, defined as a signature and one of its top five ROGL hits sharing the same or similar class of chemicals, are highlighted in bold. Self: a query signature and the connected ROGLs originated from the same experiment