Fig. 2

Twenty-four SNPs identified in E1-E3 loci, and the regulatory region of the E4 gene. Upstream: SNPs were detected up to 5 kb upstream of the coding region; Non-synonymous: SNP variants causing a codon that produces a different amino acid; Intron: SNPs detected inside an intron; 3’ UTR: SNPs found in the 3’UTR; 5’UTR: SNPs was found in the 5’ UTR; Splice Site Region: sequence variants in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron