Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location

Table 4 Biological meaning of co-expressed genes in perirenal adipose tissue of pigs

Biological Process	Nb of genes	E score	p-value	HF vs. LF diet
GO:0006952 ~ defense response	21	6.96	<0.001	↑
(GO:0006954 ~ inflammatory response)	(15)
(GO:0045087 ~ innate immune response)	(10)
GO:0016044 ~ membrane organization	11	3.92	<0.001
(GO:0006897 ~ endocytosis)	(10)
GO:0045087 ~ innate immune response	10	3.27	<0.001
(GO:0006956 ~ complement activation)	(5)
hsa04650:Natural killer cell mediated cytotoxicity	9	2.54	<0.001
(hsa04664:Fc epsilon RI signaling pathway)	(6)	2.54	<0.001
GO:0006468 ~ protein amino acid phosphorylation	11	2.34	0.004
(GO:0007243 ~ protein kinase cascade)	11	2.34	0.004

^aUnique annotated genes being highly correlated (correlations > |0.70|) to the eigengene of the yellow small module (Table 3) were inferred for their gene ontology (GO) terms for biological processes. Functional clusters having enrichment (E) score > 2 and modified Fisher exact p-value less than 0.01 were indicated. All genes were up-regulated (↑) in perirenal adipose tissue when pigs were fed a high-fat high-fiber (HF) diet compared with a low-fat high-starch (LF) diet