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Table 6 Candidates for upstream regulatory roles in functional pathways altered by diets

From: Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location

Genes proposed as regulatory candidatesa

Associated biological processes

SREBF1, MLXIPL, PPARδ, PPARα, PPARγ, USF1, OGT, GALNT1, PPP1R1A, PPP1R3C, B4GALT5, FGFR4

Glucose metabolic process

SREBF1, MLXIPL, PPARδ, PPARα, PPARγ, RXRA, RXRG, SREBF2, GATA4

Co-factor metabolic processes related to lipids and cholesterol

RXRA, RXRG, RARA, OGT

Response to organic substances

MLXIPL, GLOD4, NRF1, PPARGC1A, ACOX2

Phosphorus metabolic process

PPARδ, OGT, NFE2L2, RARA, MEF2A, MEF2C, MEF2D, ASNS, ZNF268, EBAG9, DLC1, MASP1

Regulation of apoptosis and cell death

PPARδ, MLXIPL, MAFG, KLF13, CCDC85B, ZNF268, IKZF1, COPS2, NFYA

Cell cycle process

OGT, GALNT1, NFE2L2, UBL4A, ASNS, NR1H3, B4GALT5, RFN10, ZNF268, FEM1A, TOMM7

Protein metabolic process

SREBF1, UBL4A, TOMM7

Protein transport

PPARδ, NRF1, NFE2L2, PPARGC1A

Response to stress

PPARα, PPARγ, NFE2L1, IL25

Defense response, inflammatory response

PPARÎł, MEF2A, CNIH, MASP1, FGFR4

Innate immune response

  1. aThe lists of differentially-expressed genes in porcine perirenal (PRAT) or subcutaneous (SCAT) adipose tissues in response to diet were automatically confronted to the academic information on regulations and reactions in mammalian cell signaling. Genes that were able to regulate a significant number of the differentially-expressed genes were proposed as upstream regulatory candidates. The biological processes in which these genes could be involved were indicated as referenced in the gene ontology (GO) Entrez database. The complete lists of candidates are given in Additional file 5: Table S5 for PRAT and Additional file 6: Table S6 for SCAT