Fig. 6

Heatmap apoptosis and cell proliferation: this heatmap demonstrates the change in expression patterns of genes involved in cell proliferation or programmed cell death that displayed differential expression in at least one acclimation time point (7d, 28d, or 56d) when fish acclimated to the multi-stressor treatment (n = 4) were compared to fish in the control treatments (n = 4). Genes associated with the gene ontology term cell death (GO:0008219) are represented by (−) and cell proliferation (GO:0008283) are represented by (+). Fold change is log₂ adjusted with genes showing significant up-regulation depicted in yellow and genes showing a significant down-regulation in blue (FDR ≤ 0.05). Genes whose level of expression did not differ significantly between control and multi-stressor treatments are shown in white. The number of gene variants identified in the annotated transcriptome that were associated with the same gene name are indicated in parentheses next the gene symbol