Fig. 1
Nur77 modulates inflammatory gene expression in macrophages. a Heatmap of the top 25 up- and downregulated genes in Nur77-KO compared with WT BMM. The changes in mRNA abundance in Nur77-KO compared to WT BMM were determined by microarray analysis. The color-coded scale (green indicates downregulation and red indicates upregulation) for the log2-transformed expression values, normalized per gene, is indicated at the right of the figure. b Increased and decreased biological functions in Nu77-KO compared to WT BMM identified by IPA downstream effects analysis. The color-coded scale at the left of the figure reflects the direction of change for the function, based on the regulation z-score (orange indicates upregulation and blue indicates downregulation, white represents a z-score of zero and grey represents not available). The size of the box reflects the p-values (large box, small p-value)