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Fig. 5 | BMC Genomics

Fig. 5

From: Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance

Fig. 5

Rac1 is an upstream regulator activated in Nur77-KO BMM resulting in enhanced phagocytosis in these cells. a Upstream regulators in Nur77-KO compared to WT BMM identified by IPA upstream regulator analysis. The bias-corrected z-score and the p-value were calculated as described in Additional file 1: Table S4. b Active Rac1 levels were determined in the presence and absence of the Rac1 inhibitor 553502. c Phagocytosis of FITC-labeled uropathogenic E. coli bacteria by WT and Nur77-KO BMM was measured by flow cytometry and the phagocytosis index was calculated as the percentage of cells with internalized bacteria times the mean fluorescence intensity. Data are expressed as mean ± S.D. ns, not significant, ***p < 0.001

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BMC Genomics

ISSN: 1471-2164

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