Fig. 6From: Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and toleranceRole of Nur77 in macrophages. Nur77 modulates the inflammatory state of macrophages through multiple mechanisms, decreases collagen production by lowering TIMP1-3 and collagen mRNA expression, and lowers Rac1 activity resulting in decreased phagocytosis capacity. Green indicates a protective effect and red depicts a negative effect of Nur77 expressionBack to article page