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Fig. 6 | BMC Genomics

Fig. 6

From: Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance

Fig. 6

Role of Nur77 in macrophages. Nur77 modulates the inflammatory state of macrophages through multiple mechanisms, decreases collagen production by lowering TIMP1-3 and collagen mRNA expression, and lowers Rac1 activity resulting in decreased phagocytosis capacity. Green indicates a protective effect and red depicts a negative effect of Nur77 expression

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