Table 1 Top 20 human disease pathway gene sets identified with GSEA that are upregulated in Nur77-KO vs WT BMM
Human disease pathways | NES | p-value | Adjusted p-value | Molecules contributing to the pathway |
|---|---|---|---|---|
Birth weight | 2.060 | 0.002 | 0.007 | NPY,H19,SERPINH1,GHR,IGF2 |
Diabetes mellitus type 1 | 1.993 | <0.001 | 0.015 | NPY,CXCL12,DCN,HP,CALD1,IGF2,TAF5L, RAGE,VWF,CBLB,ENPP1,VEGFA,AGER,VDR, SOD3 |
Proteinuria | 1.856 | <0.001 | 0.090 | NPY,DCN,HP,ADM,RAGE,ENPP1,VEGFA,AGER |
Diabetic nephropathies | 1.854 | 0.002 | 0.068 | DCN,HP,CCL5,MPO,CALD1,MMP9,ADM,RAGE,VWF,ENPP1,VEGFA,AGER,APOE |
Pulmonary disease, chronic obstructive | 1.852 | 0.007 | 0.057 | COL1A1,MPO,SERPINE2,MMP9,GSTM1,TIMP2,VDR, SOD3 |
Carotid artery diseases | 1.840 | 0.003 | 0.054 | NPY,CXCL12,MMP3,MMP9 |
Coronary disease | 1.826 | 0.003 | 0.058 | NPY,PDGFRA,VLDLR,HP,COL3A1,MMP2, CDKN2B,CDKN2A,F7,MMP3,MMP9,F2R, HMGCR,VWF,ENPP1,VEGFA,APOE,VDR,LDLR,ESR1,SCARB1 |
Macular degeneration | 1.818 | <0.001 | 0.056 | C2,HTRA1,MMP9,VEGFA,APOE,ERCC6 |
Fracture bone | 1.804 | 0.004 | 0.058 | COL1A1,COL1A2,TNFRSF11B,MMP9 |
Diabetic angiopathies | 1.798 | 0.007 | 0.056 | NPY,HP,F7,VWF,VEGFA,AGER |
Diabetic retinopathy | 1.791 | 0.009 | 0.055 | NPY,RAGE,VEGFA,AGER |
Scleroderma systemic | 1.789 | 0.012 | 0.052 | SPARC,FBN1,COL1A2,CCL5,FN1,IL1A |
Glucose intolerance | 1.789 | 0.011 | 0.048 | NPY,GHR |
Carcinoma ductal breast | 1.788 | 0.005 | 0.045 | MMP2,MMP9,ATM,VEGFA |
Osteoarthritis | 1.766 | 0.004 | 0.055 | COL1A1,WISP1,MMP2,ENPP1,VDR,COL2A1 |
Carcinoma hepatocellular | 1.736 | 0.011 | 0.072 | HP,TFRC,F7,IGF2,HMGCR,APC,GSTM1 |
Osteoporosis, postmenopausal | 1.724 | 0.012 | 0.078 | COL1A1,TNFRSF11B,PLXNA2,VDR,ESR1, CALCA |
Hematologic neoplasms | 1.683 | 0.021 | 0.116 | CXCL12,HPSE,GSTM1 |
Cognition disorders | 1.678 | 0.019 | 0.117 | VLDLR,MPO,BCHE,HMGCR,APOE,PRNP,DRD4, DTNBP1,CPOX |
Angina, unstable | 1.672 | 0.017 | 0.118 | COL3A1,F7,MMP3,TAF1 |