Table 2 IPA downstream effects analysis performed on genes differentially expressed in distal gut of Atlantic salmon
From: Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon
Diet/Function | Predicted activation state | Activation z-score | P-value | Number of genesa | ||
|---|---|---|---|---|---|---|
consistentb | inconsistentc | unknownd | ||||
S45 (diet with 45 % of soy protein concentrate) | ||||||
synthesis of steroid | Increased | 2.0 | 2.2E-03 | 4 | 0 | 4 |
concentration of triacylglycerol | Decreased | −2.4 | 1.1E-03 | 8 | 1 | 0 |
B45 (diet with 45 % of bean protein concentrate) | ||||||
cell-cell adhesion | Decreased | −2.6 | 8.0E-07 | 7 | 0 | 7 |
growth of epithelial tissue | Decreased | −2.4 | 3.2E-05 | 17 | 7 | 2 |
development of blood vessel | Decreased | −2.1 | 3.5E-05 | 16 | 6 | 4 |
cell movement of epithelial cells | Decreased | −2.0 | 2.7E-05 | 8 | 2 | 0 |
cell death of smooth muscle cells | Decreased | −2.1 | 1.3E-03 | 6 | 1 | 0 |
apoptosis of connective tissue cells | Decreased | −2.1 | 3.3E-03 | 8 | 2 | 1 |
Soybean meal (SBM) diet | ||||||
proliferation of cells | Increased | 2.4 | 4.7E-15 | 125 | 90 | 52 |
binding of DNA | Increased | 2.3 | 1.5E-05 | 28 | 14 | 6 |
synthesis of protein | Increased | 2.1 | 6.6E-07 | 22 | 10 | 12 |
synthesis of lipid | Increased | 2.4 | 1.6E-06 | 30 | 15 | 20 |
metabolism of carbohydrate | Increased | 2.6 | 1.5E-04 | 16 | 4 | 30 |
organization of cytoplasm | Increased | 2.3 | 2.4E-04 | 38 | 21 | 38 |
cellular homeostasis | Increased | 2.4 | 2.0E-05 | 43 | 27 | 37 |
cell movement | Increased | 3.4 | 1.1E-07 | 87 | 47 | 15 |
cell death | Decreased | −2.1 | 6.5E-14 | 124 | 88 | 36 |
autophagy | Increased | 2.5 | 1.6E-04 | 18 | 6 | 6 |