Skip to main content

Table 3 Transcriptomic alterations of cholesterol and LC-PUFA biosynthesis pathways in distal gut of Atlantic salmon

From: Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon

Pathway/Gene Gene fold change relative to fish meal (FM) dieta
S45 S34B11 S22B22 S11B34 B45 SBM
Cholesterol biosynthesis
 FDFT1, farnesyl-diphosphate farnesyltransferase 1 1.8      2.9
 CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1 3.1 2.3     2.6
 TM7SF2, transmembrane 7 superfamily member 2 2.1 1.8 1.7    1.5
 MSMO1, methylsterol monooxygenase 1      2.5 2.4
 NSDHL, NAD(P) dependent steroid dehydrogenase-like       2.4
 SC5D, sterol-C5-desaturase 2.5 1.9     1.9
 DHCR7, 7-dehydrocholesterol reductase 1.9 1.9 2.2 1.9 1.6 1.6
LC-PUFA biosynthesis
 ACSBG2, acyl-CoA synthetase bubblegum family member 2     15.3   
 ACSL5, acyl-CoA synthetase long-chain family member 5       −4.2
 ACSL6, acyl-CoA synthetase long-chain family member 6       −1.6
 CYB5A, cytochrome b5 type A (microsomal)       1.7
 CYB5R3, cytochrome b5 reductase 3 1.6      1.5
 FADS2, fatty acid desaturase 2 2.1 2.0 2.4    
 SLC27A2, solute carrier family 27 (fatty acid transporter), member 2 1.7 1.6     
  1. S45, S34B11, S22B22, S11B34, B45 and SBM are diets with 45 % of soy protein concentrate (SPC), 34 % SPC and 11 % of bean protein concentrate (BPC), 22 % SPC and 22 % BPC, 11 % SPC and 34 % BPC, 45 % BPC, and enriched with soybean meal (SBM), respectively
  2. aOnly genes considered as differentially expressed (adjusted P-value < 0.2, absolute fold change ≥ 1.4) are reported