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Table 3 Transcriptomic alterations of cholesterol and LC-PUFA biosynthesis pathways in distal gut of Atlantic salmon

From: Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon

Pathway/Gene

Gene fold change relative to fish meal (FM) dieta

S45

S34B11

S22B22

S11B34

B45

SBM

Cholesterol biosynthesis

 FDFT1, farnesyl-diphosphate farnesyltransferase 1

1.8

    

2.9

 CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1

3.1

2.3

   

2.6

 TM7SF2, transmembrane 7 superfamily member 2

2.1

1.8

1.7

  

1.5

 MSMO1, methylsterol monooxygenase 1

    

2.5

2.4

 NSDHL, NAD(P) dependent steroid dehydrogenase-like

     

2.4

 SC5D, sterol-C5-desaturase

2.5

1.9

   

1.9

 DHCR7, 7-dehydrocholesterol reductase

1.9

1.9

2.2

1.9

1.6

1.6

LC-PUFA biosynthesis

 ACSBG2, acyl-CoA synthetase bubblegum family member 2

   

15.3

  

 ACSL5, acyl-CoA synthetase long-chain family member 5

     

−4.2

 ACSL6, acyl-CoA synthetase long-chain family member 6

     

−1.6

 CYB5A, cytochrome b5 type A (microsomal)

     

1.7

 CYB5R3, cytochrome b5 reductase 3

1.6

    

1.5

 FADS2, fatty acid desaturase 2

2.1

2.0

2.4

   

 SLC27A2, solute carrier family 27 (fatty acid transporter), member 2

1.7

1.6

    
  1. S45, S34B11, S22B22, S11B34, B45 and SBM are diets with 45 % of soy protein concentrate (SPC), 34 % SPC and 11 % of bean protein concentrate (BPC), 22 % SPC and 22 % BPC, 11 % SPC and 34 % BPC, 45 % BPC, and enriched with soybean meal (SBM), respectively
  2. aOnly genes considered as differentially expressed (adjusted P-value < 0.2, absolute fold change ≥ 1.4) are reported