Evidence for contribution of common genetic variants within chromosome 8p21.2-8p21.1 to restricted and repetitive behaviors in autism spectrum disorders

Tao, Yu; Gao, Hui; Ackerman, Benjamin; Guo, Wei; Saffen, David; Shugart, Yin Yao

doi:10.1186/s12864-016-2475-y

Table 4 List of the most significant associations with IS (P-value < E-06) in the AGRE cohort

From: Evidence for contribution of common genetic variants within chromosome 8p21.2-8p21.1 to restricted and repetitive behaviors in autism spectrum disorders

CHR	SNP	BP (hg19)	Effect allele	F^a	Nearest Gene	beta	se	P(wald)	type
8	rs62503729	27083792	A	0.901	STMN4 (10 kb downstream)	-1.0192	0.1925	1.39E-07	Imputed
8	rs13278976	27085479	T	0.901	STMN4 (10 kb downstream)	-1.0129	0.1924	1.64E-07	Imputed
8	rs13270725	27085587	C	0.901	STMN4 (10 kb downstream)	-1.0129	0.1924	1.64E-07	Imputed
8	rs35240189	27079834	G	0.896	STMN4 (10 kb downstream)	-0.9852	0.1872	1.65E-07	Imputed
8	rs2322600	27139408	G	0.14	TRIM35 (3 kb downstream)	0.9316	0.1772	1.71E-07	Imputed
8	rs34759235	27071936	G	0.896	STMN4 (10 kb downstream)	-0.9748	0.1879	2.45E-07	Imputed
8	rs4733041	27113678	A	0.894	STMN4 (intron)	-0.9802	0.1897	2.75E-07	Imputed
8	rs11135988	27112923	T	0.894	STMN4 (intron)	-0.9798	0.1897	2.78E-07	Imputed
8	rs12542830	27111998	C	0.894	STMN4 (intron)	-0.9792	0.1897	2.81E-07	Imputed
8	rs12542220	27111546	C	0.894	STMN4 (intron)	-0.9789	0.1897	2.82E-07	Imputed
8	rs12542148	27111265	C	0.894	STMN4 (intron)	-0.9787	0.1896	2.83E-07	Imputed
8	rs12675791	27094644	G	0.894	STMN4 (intron)	-0.9755	0.1892	2.89E-07	Imputed
8	rs12549968	27108413	C	0.894	STMN4 (intron)	-0.9767	0.1895	2.94E-07	Imputed
8	rs2322606	27186923	A	0.169	PTK2B (intron)	0.8255	0.1602	2.97E-07	Genotyped^a
5	rs747919	66792177	C	0.426	LOC359819 (200 kb)	0.6232	0.1210	2.98E-07	Imputed
8	rs12550034	27096145	G	0.894	STMN4 (intron)	-0.9740	0.1891	2.99E-07	Imputed
6	rs11970233	7962158	C	0.802	TXNDC5 (intron)	-0.7461	0.1451	3.11E-07	Imputed
8	rs3739213	27100014	G	0.894	STMN4 (intron)	-0.9739	0.1894	3.11E-07	Imputed
8	rs12541011	27104497	C	0.894	STMN4 (intron)	-0.9734	0.1893	3.12E-07	Imputed
8	rs4733039	27101046	C	0.894	STMN4 (intron)	-0.9725	0.1892	3.15E-07	Imputed
8	rs1562331	27097746	G	0.894	STMN4 (intron)	-0.9697	0.1889	3.27E-07	Genotyped^a
6	rs9505329	7960742	G	0.803	TXNDC5 (intron)	-0.7343	0.1451	4.73E-07	Imputed
8	rs10097861	27188518	G	0.19	PTK2B (intron)	0.7654	0.1514	4.86E-07	Genotyped^a
6	rs13437591	7959662	G	0.803	TXNDC5 (intron)	-0.7324	0.1451	5.14E-07	Imputed
6	rs155476	7961189	C	0.745	TXNDC5 (intron)	-0.6684	0.1327	5.36E-07	Genotyped^a
6	rs429530	7956571	G	0.803	TXNDC5 (intron)	-0.7304	0.1453	5.63E-07	Imputed
8	rs11782061	27188980	T	0.191	PTK2B (intron)	0.7618	0.1516	5.66E-07	Imputed
6	rs155495	7945804	G	0.805	TXNDC5 (intron)	-0.7299	0.1458	6.30E-07	Imputed
6	rs155500	7949075	C	0.805	TXNDC5 (intron)	-0.7294	0.1461	6.76E-07	Imputed
8	rs4733043	27113883	G	0.888	STMN4 (intron)	-0.9248	0.1864	7.95E-07	Imputed
8	rs12541668	27105399	C	0.901	STMN4 (intron)	-0.9727	0.1967	8.63E-07	Imputed
8	rs3739214	27101279	C	0.901	STMN4 (intron)	-0.9715	0.1966	8.73E-07	Imputed
6	rs155491	7943686	G	0.804	TXNDC5 (intron)	-0.7166	0.1452	8.95E-07	Imputed

^aF: frequency of the effect allele

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