Fig. 9

LATS1, MOB1A, OS-2 immunolabeling of normal and mutant retinas. A LATS1 labels the INL and GCL/NFL in normal retina. In mutants, there is additional faint labeling of the photoreceptor and RPE layers. B Low levels of MOB1A labeling are present in the normal retina, and increase in mutants in the same layers which express LATS1. C The OS-2 antibody labels a subpopulation of cones (S-cones; arrowheads) in normal, xlpra2 and rcd1 (C1-3). Dual labeling with OS-2 and LATS1 antibodies in normal shows labeling in different retinal domains (C4). In erd, OS-2 labels the inner and outer segments of the entire photoreceptor population (C5, *), and colocalizes with LATS1 (C6, *). RPE = retinal pigment epithelium, ONL = outer nuclear layer, INL = inner nuclear layer, NFL = nerve fiber layer. Scale bar = 40 μm for (A, B, C)