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Fig. 16 | BMC Genomics

Fig. 16

From: Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

Fig. 16

Mx1 sequence alignment of A2G and the eight CC founder strains. Mx1 alleles of CC founder strains in comparison to the A2J allele are shown. The mouse Mx1 gene has 14 exons (blue). Changes of the nucleotide sequence in exons (yellow) result in amino acid exchanges indicated below by showing the respective amino acid exchange. PWK/PhJ exhibits one amino acid exchange relative to A2J, CAST/EiJ two changes at different positions. A premature stop codon is present in WSB/EiJ leading to a truncated MX1 protein. The other strains (A/J, C56BL/6J, 129S1/SvImJ and NOD/ShiLtJ) possess a deletion between the 8th and the 12th exon resulting in a non-functional protein. The graph was created based on data from ncbi.com and [34]

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BMC Genomics

ISSN: 1471-2164

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