Fig. 5From: Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ miceConstant high viral load in highly and intermediate susceptible and viral clearance in resistant strains. Eight to twelve weeks old female mice of the eight CC founder strains were infected intra-nasally with 1 × 101 FFU of influenza H3N2 virus. Lung samples were taken for mock infected animals on day 3 post treatment and on day 3, 5, and 8 p.i.. Lungs of mice of all CC founder strains showed comparable high viral loads at 105 FFU/lung from day 3 until day 5 p.i.. NZO/HlLtJ and PWK/PhJ had lower viral loads and cleared virus until day 8 p.i.. Each data point represents the measurement of one animal; mean and standard error of the mean are shown for each time point and strainBack to article page