Table 3 Average scoring of lesions by histopathology and of virus antigen expression by immunohistochemistry in lung tissue of C57BL/6Â J, 129S1/SvImJ and CAST/EiJ mice infected with H3N2
| Â | Â | Histopathology score | IHC score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Strain | Day post infection or mock control | Extent alveolitis/alveolar damage | Severity of alveolitis | Severity of alveolar edema | Presence of interstitial edema | Presence of type II pneumocyte hyperplasia | Severity of bronchiolitis/bronchitis | Degree of peribronchial/perivascular cuffing | Alveoli | Bronchioles and bronchi |
C57BL/6J | mock d3 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 |
| Â | d3 | 1.7 | 2.0 | 0.3 | 1.0 | 0.7 | 2.7 | 1.7 | 7.0 | 1.0 |
| Â | d5 | 2.0 | 3.0 | 1.0 | 1.0 | 0.3 | 2.3 | 2.0 | 9.7 | 1.3 |
| Â | d8 | 3.0 | 3.0 | 1.0 | 1.0 | 1.0 | 2.3 | 1.7 | 3.0 | 1.7 |
129S1/SvImJ | mock d3 | 1.3 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Â | d3 | 1.7 | 2.0 | 0.3 | 0.7 | 0 | 1.7 | 1.3 | 4 | 0.3 |
| Â | d5 | 1.7 | 2.3 | 1.0 | 1.0 | 0.3 | 3.0 | 2.0 | 10.7 | 1.3 |
| Â | d8 | 3.0 | 3.0 | 1.0 | 1.0 | 1.0 | 2.7 | 2.0 | 10.3 | 2.0 |
CAST/EiJ | mock d3 | 0.3 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Â | d3 | 1.7 | 1.7 | 0.7 | 1.0 | 0.3 | 1.0 | 0.7 | 12 | 1.3 |
| Â | d5 | 2.7 | 1.7 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 18.7 | 1.3 |