Skip to main content

Table 3 Average scoring of lesions by histopathology and of virus antigen expression by immunohistochemistry in lung tissue of C57BL/6 J, 129S1/SvImJ and CAST/EiJ mice infected with H3N2

From: Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

   Histopathology score IHC score
Strain Day post infection or mock control Extent alveolitis/alveolar damage Severity of alveolitis Severity of alveolar edema Presence of interstitial edema Presence of type II pneumocyte hyperplasia Severity of bronchiolitis/bronchitis Degree of peribronchial/perivascular cuffing Alveoli Bronchioles and bronchi
C57BL/6J mock d3 0 0 0 1.0 0 0 0 0 0
  d3 1.7 2.0 0.3 1.0 0.7 2.7 1.7 7.0 1.0
  d5 2.0 3.0 1.0 1.0 0.3 2.3 2.0 9.7 1.3
  d8 3.0 3.0 1.0 1.0 1.0 2.3 1.7 3.0 1.7
129S1/SvImJ mock d3 1.3 1.0 0 0 0 0 0 0 0
  d3 1.7 2.0 0.3 0.7 0 1.7 1.3 4 0.3
  d5 1.7 2.3 1.0 1.0 0.3 3.0 2.0 10.7 1.3
  d8 3.0 3.0 1.0 1.0 1.0 2.7 2.0 10.3 2.0
CAST/EiJ mock d3 0.3 0.3 0 0 0 0 0 0 0
  d3 1.7 1.7 0.7 1.0 0.3 1.0 0.7 12 1.3
  d5 2.7 1.7 1.0 1.0 1.0 1.0 1.0 18.7 1.3