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Fig. 5 | BMC Genomics

Fig. 5

From: A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration

Fig. 5

Differential gene expression patterns in response to PHx in the three dietary groups. a Average differential expression was computed at each time point post PHx, based on comparing PHx samples and the corresponding excised LLM tissue at t = 0 from the same animals. The genes are ordered based on the expression patterns in the Carbohydrate group. Coarse-grain visualization of the differential expression at this scale suggests a broadly similar dynamic patterns of response in all the three dietary groups. The specific differences are explored systematically using a COMPACT matrix (Fig. 6). Of note are the significantly lower upregulation at 24 h in the Ethanol group (highlighted by the asterisks). b A total of 27 discretized expression patterns based on three possible levels of regulation (up, down and no change) at each of the three time points (1, 6 and 24 h post PHx). The pattern counts are based on a differential regulation threshold of 1.75 fold. There appears to be a broad similarity of dominant patterns across the three dietary groups. Of note are the significantly fewer genes in the Ethanol group for the dominant patterns corresponding to 24 h upregulation (highlighted by the # symbol). (two-tailed Z-test *p-value <0.0002)

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