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Fig. 8 | BMC Genomics

Fig. 8

From: A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration

Fig. 8

Analysis of comparative patterns corresponding to differential regulation at 6 h and 24 h, but not earlier at 1 h. A set of 5611 genes was distributed across the selected subset of patterns from section e of the overall COMPACT matrix shown in Fig. 7. a Circular representation of the comparative patterns using the CIRCOS tool. The length of the arcs is proportional to the number of genes showing the corresponding pattern. The width of the ribbons connecting the arcs corresponding to the comparative pattern count, i.e., the number of genes showing the corresponding differential regulatory patterns in the two dietary groups. The arcs are arranged such that the no-differential-regulation pattern separates the upregulated patterns (upper segment) and the down regulatory patterns (lower segment). Absence of dominant ribbons crossing the two segments demonstrates that relatively few genes switch the direction of PHx-induced differential regulation between the dietary groups. b Ethanol group shows a lower number of up regulated genes (2021) than the Control group (2675), as indicated by the net sum of corresponding arc lengths. In comparison, the difference was lower in the total down regulation between the Ethanol (1982) and Carbohydrate (1764) groups. c-h The dominant gene sets within the six differential expression patterns are highlighted: c transient upregulation, d transient downregulation, e persistent upregulation, f persistent downregulation, g late upregulation, and h late downregulation. In each set, a select list of statistically over-represented functional annotation information is indicated

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