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Fig. 1 | BMC Genomics

Fig. 1

From: Targeted alignment and end repair elimination increase alignment and methylation measure accuracy for reduced representation bisulfite sequencing data

Fig. 1

RRBS concept and workflow. Genomic DNA is first digested by MSP1 which cuts at CCGG sites. These fragments are end-repaired, A-tailed, and adapter-attached and then bisulfite treated. The unmethylated C is converted to U (T) and methylated C is unchanged. The blue bases are from media and are not real biological signal that needed to be removed

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