Skip to main content

Table 1 Gene expression pattern differences between ChIA-PET CTCF loop-enclosed, loop-flanking and loop-distal genes

From: CTCF-mediated chromatin loops enclose inducible gene regulatory domains

Cell line

Measure

Loops

Flanks

Distal

Flanks/Loops

Flanks/Distal

Loops/Distal

FCa

P-valueb

FC

P-value

FC

P-value

K562

Gene Count

4378

4767

6466

 

Median Expression (FPKM)c

0.853

1.698

0.091

1.99

5.89e–07

18.66

1.25e–93

9.37

9.74e–56

Median TSId

0.754

0.6756

0.7565

0.9

5.3e–37

0.89

8.23e–47

1.0

0.27

Median CVe

1.142

0.8357

1.192

0.73

1.72e–36

0.7

1.34e–56

0.96

0.01

MCF7

Gene Count

5469

6490

3847

 

Median Expression (FPKM)

0.467

2.18

0.413

4.67

1.92e–65

5.28

1.07e–90

1.13

9.04e–06

Median TSI

0.7818

0.6721

0.7549

0.86

1.65e–98

0.89

3.16e–46

1.04

1.19e–05

Median CV

1.331

0.8214

1.178

0.62

3.92e–100

0.7

9.91e–56

1.13

7.65e–04

  1. aFC: Fold Change of the medians
  2. b P-value based on Wilcoxon rank sum test with continuity correction
  3. cFPKM: Fragments Per Kilobase per Million mapped reads
  4. dTSI: Tissue Specificity Index
  5. eCV: Coefficient of Variation