Fig. 5

Hierarchical clustering analysis of the gene signatures associated with the isoform expression pattern of PRICKLE1. 1059 genes are significantly correlated with the ratio of uc010skw.1 and uc001rnl.2, and are not associated with PAM50 subtype or RIN score. PRICKLE1-based clusters identified by K-means clustering were color coded consistent with Fig. 3a. RIN group displays samples with high (>8.7, median RIN) and low RIN score (≤8.7). Four gene expression signatures (a-d, shown by side color bars) are identified to be involved in cancer hallmarks