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Table 6 List of plausible candidate genes

From: Detailed phenotyping identifies genes with pleiotropic effects on body composition

Group Lead SNP OAR POS Gene code Gene name Comments
Group1 1st 16 31882270 GHR Growth hormone receptor precursor Lead SNP
Group1 1st 8 73201627 UST uronyl-2-sulfotransferase Linear Index SNP
Group1 2nd 14 34761382 LCAT lecithin-cholesterol acyltransferase Lead SNP
Group1 3rd 11 26445930 SLC16A13 (TP53 a) Solute carrier family 16 member Lead SNP
Group1 3rd 13 700413 PLCB1 Phosphoinositide phospholipase C Linear Index SNP
Group1 3rd 5 28332019 SNX24 Sorting nexin-24 Linear Index SNP
Group1 3rd 6 40133729 PACRGL PARK2 Co-Regulated-Like Linear Index SNP
Group1 3rd 6 44672729 PI4K2B phosphatidylinositol 4-kinase type 2 beta Linear Index SNP
Group1 4 th 6 43309694 PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Linear Index SNP
Group1 4 th 11 26415211 ALOX12 12-lipoxygenase Fragment Linear Index SNP
Group1 4 th 11 28366019 STX8 Syntaxin 8 Linear Index SNP
Group1 4 th 1 171579973 MYH15 myosin, heavy chain 15 Linear Index SNP
Group1 4 th 6 13255764 ALPK1 alpha-kinase 1 Linear Index SNP
Group1 4 th 6 19164907 TBCK TBC1 domain containing kinase Linear Index SNP
Group1 4 th 6 23695577 PPP3CA protein phosphatase 3, Catalytic Subunit, Alpha Isozyme Linear Index SNP
Group1 4 th 6 26074029 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 Linear Index SNP
Group1 4 th 6 29441012 BMPR1B bone morphogenetic protein receptor, type IB Linear Index SNP
Group1 4 th 6 36811936 MEPE Matrix Extracellular Phosphoglycoprotein Linear Index SNP
Group1 4 th 6 37237578 NCAPG non-SMC condensin I complex, subunit G Linear Index SNP
Group1 4 th 6 37530647 LCORL Ligand Dependent Nuclear Receptor Corepressor-Like Lead SNP
Group1 4 th 6 55607047 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Linear Index SNP
Group1 4 t 6 67191744 FRYL FRY-like Linear Index SNP
Group1 4th 9 36164331 PLAG1 pleiomorphic adenoma gene 1 Linear Index SNP
Group2 5th 26 13991962 ACSL1 acyl-CoA synthetase long-chain family member 1 Lead SNP
Group2 6th 11 13223903 ACACA acetyl-CoA carboxylase alpha Linear Index SNP
Group2 6th 11 13272203    Lead SNP
Group2 6th 11 13472077 SYNRG synergin, gamma Linear Index SNP
Group2 7th 11 49936709 FASN Fatty acid synthase Fragment Lead SNP
Group2 7th 13 71732382 SGK2 serum/glucocorticoid regulated kinase 2 Linear Index SNP
Group2 7th 24 33535204 MLXIPL MLX interacting protein-like Linear Index SNP
Group2 7th 5 4503837 ISYNA1 Inositol-3-phosphate synthase 1 Linear Index SNP
Group2 8th 6 15245427 SNORA70 small nucleolar RNA, H/ACA box 70 Lead SNP
Group2 8th 6 15303638 ELOVL6 ELOVL fatty acid elongase 6 Linear Index SNP
Group2 8th 6 97914579 AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 Linear Index SNP
Group3 9th 19 57102703 MRPS25 28S ribosomal protein S25, mitochondrial Lead SNP
Group3 9th 3 178861487 MB Myoglobin Linear Index SNP
Group3 10th 1 31018467 PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit Linear Index SNP
Group3 10th 2 212089089 ERBB4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 Linear Index SNP
Group3 10th 2 219569259 PLCD4 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 Lead SNP
Group3 10th 2 219741728 CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 Linear Index SNP
Group3 11th 23 5077077 NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 Linear Index SNP
Group3 11th 3 178935942 APOL6 apolipoprotein L, 6 Lead SNP
Group3 12th 11 19757132 PROCA1 Protein PROCA1 Linear Index SNP
Group3 12th 21 42744428 CAPN1 Calpain-1 catalytic subunit Linear Index SNP
Group3 12th 3 193152752 ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Linear Index SNP
Group3 12th 5 93437720 CAST Calpastatin Lead SNP
Group3 13th 18 63919438 WARS Tryptophanyl-tRNA synthetase, cytoplasmic Linear Index SNP
Group3 13th 18 64095685 BEGAIN brain-enriched guanylate kinase-associated Linear Index SNP
Group3 13th 18 64349803 DLK1 delta-like 1 homolog Linear Index SNP
Group3 13th 18 64452243 MEG3_2 maternally expressed 3 Linear Index SNP
Group3 13th 18 64496663 MEG8_2 maternally expressed 8 Lead SNP
Group3 13th 18 66755669 MARK3 MAP/microtubule affinity-regulating kinase 3 Linear Index SNP
Group4 14th 8 25030751 (LAMA4) laminin, alpha 4 Lead SNP
Group4 15th 18 6026853 MEF2A Myocyte-specific enhancer factor 2A Linear Index SNP
Group4 15th 1 373512 FARP2 FERM, RhoGEF and pleckstrin domain protein 2 Linear Index SNP
Group4 15th 22 20348430 PKD2L1 (SCD b) polycystic kidney disease 2-like 1 Lead SNP
Group4 16th 12 49339905 B3GALT6 UDP-Gal-betaGal beta 1,3-galactosyltransferase polypeptide 6 Linear Index SNP
Group4 16th 12 49639530 SAMD11 sterile alpha motif domain containing 11 Lead SNP
Group4 16th 17 63396022 MYO1H myosin IH Linear Index SNP
Group4 16th 12 49270130 GLTPD1 glycolipid transfer protein domain containing 1 Linear Index SNP
Group5 17th 14 54580893 GYS1 Glycogen synthase, muscle Lead SNP
Group5 17th 4 54562436 PPP1R3A protein phosphatase 1, regulatory (inhibitor) subunit 3A Linear Index SNP
Group5 18th 3 218656000 PNPLA3 patatin-like phospholipase domain containing 3 Lead SNP
Group5 19th 21 39759701 FADS2 Fatty acid desaturase 2 Lead SNP
Group5 20th 19 30808702 5S_rRNA RNA, 5S ribosomal Lead SNP
Group5 21th 20 44129579 SMIM13 small integral membrane protein 13 Lead SNP
Group5 21th 20 44237093 ELOVL2 ELOVL fatty acid elongase 2 Linear Index SNP
Group5 22th 21 14965281    Lead SNP
Group5 23th 15 47513135 U1 RNA, variant U1 Lead SNP
Group5 23th 25 29372500 USP54 ubiquitin specific peptidase 54 Linear Index SNP
  1. a TP53 and b SCD genes which were mapped near this region could be the plausible candidates