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Table 6 List of plausible candidate genes

From: Detailed phenotyping identifies genes with pleiotropic effects on body composition

Group

Lead SNP

OAR

POS

Gene code

Gene name

Comments

Group1

1st

16

31882270

GHR

Growth hormone receptor precursor

Lead SNP

Group1

1st

8

73201627

UST

uronyl-2-sulfotransferase

Linear Index SNP

Group1

2nd

14

34761382

LCAT

lecithin-cholesterol acyltransferase

Lead SNP

Group1

3rd

11

26445930

SLC16A13 (TP53 a)

Solute carrier family 16 member

Lead SNP

Group1

3rd

13

700413

PLCB1

Phosphoinositide phospholipase C

Linear Index SNP

Group1

3rd

5

28332019

SNX24

Sorting nexin-24

Linear Index SNP

Group1

3rd

6

40133729

PACRGL

PARK2 Co-Regulated-Like

Linear Index SNP

Group1

3rd

6

44672729

PI4K2B

phosphatidylinositol 4-kinase type 2 beta

Linear Index SNP

Group1

4 th

6

43309694

PPARGC1A

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Linear Index SNP

Group1

4 th

11

26415211

ALOX12

12-lipoxygenase Fragment

Linear Index SNP

Group1

4 th

11

28366019

STX8

Syntaxin 8

Linear Index SNP

Group1

4 th

1

171579973

MYH15

myosin, heavy chain 15

Linear Index SNP

Group1

4 th

6

13255764

ALPK1

alpha-kinase 1

Linear Index SNP

Group1

4 th

6

19164907

TBCK

TBC1 domain containing kinase

Linear Index SNP

Group1

4 th

6

23695577

PPP3CA

protein phosphatase 3, Catalytic Subunit, Alpha Isozyme

Linear Index SNP

Group1

4 th

6

26074029

RAP1GDS1

Rap1 GTPase-GDP dissociation stimulator 1

Linear Index SNP

Group1

4 th

6

29441012

BMPR1B

bone morphogenetic protein receptor, type IB

Linear Index SNP

Group1

4 th

6

36811936

MEPE

Matrix Extracellular Phosphoglycoprotein

Linear Index SNP

Group1

4 th

6

37237578

NCAPG

non-SMC condensin I complex, subunit G

Linear Index SNP

Group1

4 th

6

37530647

LCORL

Ligand Dependent Nuclear Receptor Corepressor-Like

Lead SNP

Group1

4 th

6

55607047

ARAP2

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Linear Index SNP

Group1

4 t

6

67191744

FRYL

FRY-like

Linear Index SNP

Group1

4th

9

36164331

PLAG1

pleiomorphic adenoma gene 1

Linear Index SNP

Group2

5th

26

13991962

ACSL1

acyl-CoA synthetase long-chain family member 1

Lead SNP

Group2

6th

11

13223903

ACACA

acetyl-CoA carboxylase alpha

Linear Index SNP

Group2

6th

11

13272203

  

Lead SNP

Group2

6th

11

13472077

SYNRG

synergin, gamma

Linear Index SNP

Group2

7th

11

49936709

FASN

Fatty acid synthase Fragment

Lead SNP

Group2

7th

13

71732382

SGK2

serum/glucocorticoid regulated kinase 2

Linear Index SNP

Group2

7th

24

33535204

MLXIPL

MLX interacting protein-like

Linear Index SNP

Group2

7th

5

4503837

ISYNA1

Inositol-3-phosphate synthase 1

Linear Index SNP

Group2

8th

6

15245427

SNORA70

small nucleolar RNA, H/ACA box 70

Lead SNP

Group2

8th

6

15303638

ELOVL6

ELOVL fatty acid elongase 6

Linear Index SNP

Group2

8th

6

97914579

AGPAT9

1-acylglycerol-3-phosphate O-acyltransferase 9

Linear Index SNP

Group3

9th

19

57102703

MRPS25

28S ribosomal protein S25, mitochondrial

Lead SNP

Group3

9th

3

178861487

MB

Myoglobin

Linear Index SNP

Group3

10th

1

31018467

PRKAA2

protein kinase, AMP-activated, alpha 2 catalytic subunit

Linear Index SNP

Group3

10th

2

212089089

ERBB4

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Linear Index SNP

Group3

10th

2

219569259

PLCD4

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4

Lead SNP

Group3

10th

2

219741728

CYP27A1

cytochrome P450, family 27, subfamily A, polypeptide 1

Linear Index SNP

Group3

11th

23

5077077

NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

Linear Index SNP

Group3

11th

3

178935942

APOL6

apolipoprotein L, 6

Lead SNP

Group3

12th

11

19757132

PROCA1

Protein PROCA1

Linear Index SNP

Group3

12th

21

42744428

CAPN1

Calpain-1 catalytic subunit

Linear Index SNP

Group3

12th

3

193152752

ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Linear Index SNP

Group3

12th

5

93437720

CAST

Calpastatin

Lead SNP

Group3

13th

18

63919438

WARS

Tryptophanyl-tRNA synthetase, cytoplasmic

Linear Index SNP

Group3

13th

18

64095685

BEGAIN

brain-enriched guanylate kinase-associated

Linear Index SNP

Group3

13th

18

64349803

DLK1

delta-like 1 homolog

Linear Index SNP

Group3

13th

18

64452243

MEG3_2

maternally expressed 3

Linear Index SNP

Group3

13th

18

64496663

MEG8_2

maternally expressed 8

Lead SNP

Group3

13th

18

66755669

MARK3

MAP/microtubule affinity-regulating kinase 3

Linear Index SNP

Group4

14th

8

25030751

(LAMA4)

laminin, alpha 4

Lead SNP

Group4

15th

18

6026853

MEF2A

Myocyte-specific enhancer factor 2A

Linear Index SNP

Group4

15th

1

373512

FARP2

FERM, RhoGEF and pleckstrin domain protein 2

Linear Index SNP

Group4

15th

22

20348430

PKD2L1 (SCD b)

polycystic kidney disease 2-like 1

Lead SNP

Group4

16th

12

49339905

B3GALT6

UDP-Gal-betaGal beta 1,3-galactosyltransferase polypeptide 6

Linear Index SNP

Group4

16th

12

49639530

SAMD11

sterile alpha motif domain containing 11

Lead SNP

Group4

16th

17

63396022

MYO1H

myosin IH

Linear Index SNP

Group4

16th

12

49270130

GLTPD1

glycolipid transfer protein domain containing 1

Linear Index SNP

Group5

17th

14

54580893

GYS1

Glycogen synthase, muscle

Lead SNP

Group5

17th

4

54562436

PPP1R3A

protein phosphatase 1, regulatory (inhibitor) subunit 3A

Linear Index SNP

Group5

18th

3

218656000

PNPLA3

patatin-like phospholipase domain containing 3

Lead SNP

Group5

19th

21

39759701

FADS2

Fatty acid desaturase 2

Lead SNP

Group5

20th

19

30808702

5S_rRNA

RNA, 5S ribosomal

Lead SNP

Group5

21th

20

44129579

SMIM13

small integral membrane protein 13

Lead SNP

Group5

21th

20

44237093

ELOVL2

ELOVL fatty acid elongase 2

Linear Index SNP

Group5

22th

21

14965281

  

Lead SNP

Group5

23th

15

47513135

U1

RNA, variant U1

Lead SNP

Group5

23th

25

29372500

USP54

ubiquitin specific peptidase 54

Linear Index SNP

  1. a TP53 and b SCD genes which were mapped near this region could be the plausible candidates