Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential

BMC Genomics

Table 3 Numbers and vectors of DNA methylation and gene expression changes in murine hearts after birth

		Number of DMRs and transcripts pairs
	Relationship	Distal	Proximal	Intragenic	Total
d1-d7	MeDIP↑ Expression↑	89	43	28	160
	MeDIP↑ Expression↓	55	17	11	83
	MeDIP↓ Expression↑	6	6	6	18
	MeDIP↓ Expression↓	6	5	1	12
d1-w2	MeDIP↑ Expression↑	21	17	19	57
	MeDIP↑ Expression↓	14	21	9	44
	MeDIP↓ Expression↑	146	30	50	226
	MeDIP↓ Expression↓	27	119	44	190
d1-w8	MeDIP↑ Expression↑	121	23	23	167
	MeDIP↑ Expression↓	143	43	13	199
	MeDIP↓ Expression↑	245	311	118	674
	MeDIP↓ Expression↓	135	178	97	410

The summary includes the numbers of DMRs paired with corresponding transcripts changing their expression levels by at least a 1.5-fold. The relationships are visualized in Figs. 6, 7, 8
MeDIP↑/MeDIP↓ - DNA methylation gain/loss
Expression↑/Expression↓ - increase/decrease

ISSN: 1471-2164