Fig. 2

- Network Visualization, Hubs and Clustering Coefficient. a Graphical representation of ChalmyNET consisting of 9171 genes or nodes and 139019 co-expression relationships or edges. It is organized into a major connected component where most of the genes are located and a multitude of small components. b Network hubs. We have represented in yellow hub genes characterized by being co-expressed with a large number of other genes. Note that hub genes are located in specific regions of the network. c Authoritative hubs. Those hubs whose neighbours are highly connected, are mainly located at the core of the network. These authoritative hubs are represented in red. d The clustering coefficient of a gene meassures the degree of co-expression among its co-expressed genes. Genes with a high clustering coefficient are coloured in darker blue than those with a low clustering coefficient. Notice that regions of genes with a high clustering coefficient overlap with those where hubs are located