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Table 1 Average response to LPS from combined Holstein and Angus cultures measured by increases in expression of immune-associated genes compared to hour 0 post-LPS

From: Differential responsiveness of Holstein and Angus dermal fibroblasts to LPS challenge occurs without major differences in the methylome

Gene symbol Gene Name Fold Changea  
Transcription and activation pathways   Hour 2 Hour 8
BIRC3 Baculoviral IAP repeat-containing protein 3 7.3 4.2
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 24.3 9.3
NFKBIZ Nuclear factor of kappa-B inhibitor zeta 11.7 3.2
NFKB2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 - - 2.8
NFKBID Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 2.3 - -
Cytokines, chemokines, and growth factors    
CCL2 Chemokine (C-C motif) ligand 2 14.9 14.6
CCL5 RANTES 49.6 132.8
CCL20 Chemokine (C-C motif) ligand 20 1102.1 3147.3
CXCL2 Chemokine (C-X-C motif) ligand 2 67.9 31.6
CXCL6 Chemokine (C-X-C motif) ligand 6 12.3 45.0
IL1A Interleukin 1, alpha 9.2 5.7
IL6 Interleukin 6 88.2 124.1
IL8 Interleukin 8 325.7 387.8
SAA3 Serum Amyloid A 3 65.1 1145.6
TNF Tumor Necrosis Factor, alpha 87.4 - -
Type I IFN-related genes    
IRF1 Interferon regulatory factor 1 12.3 4.2
IRF5 Interferon regulatory factor 5 3.0 - -
ISG15 Ubiquitin-like modifier - - 308.3
MX2 Myxovirus (influenza virus) resistance 2 - - 156.6
OAS1 2'–5'- oligoadenylate synthetase 1 - - 128.7
OAS2 2'–5'- oligoadenylate synthetase 2 - - 65.6
  1. aData obtained by RNA-Seq and presented as fold induction of the indicated gene at either 2 or 8 h post-LPS in comparison to expression levels at 0 h post-LPS. All fold changes shown are FDR < 0.05; FC > 2; and CPM >1. - - indicates FDR > 0.05, FC < 2, or CPM < 1