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Table 2 Differential gene expression (fold change) of immune-associated genes at hours 0, 2, and 8 post-LPS treatment of fibroblasts collected from Holstein animals as compared to fibroblasts collected from Angus animals

From: Differential responsiveness of Holstein and Angus dermal fibroblasts to LPS challenge occurs without major differences in the methylome

Gene Hour 0 Hour 2 Hour 8
Innate immune related genes    
CCL2 - - - - 2.9
CCL5 - - - - 5.7
CCL20 - - - - 8.6
CCL26 - - 2.8 3.6
CX3CL1 - - - - 14.8
CXCL12 −5.7 −7.4 −6.5
CXCL16 - - - - 2.3
CXCR4 −3.1 - - - -
HMGB1 −1.9 −1.9 −1.8
IFIH1 - - - - 3.6
IL1R1 - - 1.5 - -
IL8 - - - - 4.5
IRF5 2.4 2.4 2.6
MX2 - - - - 14.0
NOD1 - - 2.4 - -
TLR2 −3.5 −2.8 - -
TLR4 3.0 4.0 2.5
TLR6 1.8 - - 2.5
TNF - - 6.9 - -
TNFSF18 6.5 6.0 5.1
TNFSF4 4.4 - - 2.6
TRAF1 2.4 2.4 - -
TRAIP - - −2.7 - -
DNA Methylation associated genes    
DNMT1 −1.6 −1.5 −1.5
DNMT3A - - - - - -
DNMT3B - - - - - -
UHRF1 −2.3 −2.0 −2.0
  1. Data obtained by RNA-Seq and presented as fold change between Holstein and Angus cultures. Positive values indicate higher expression in Holstein cultures as compared to Angus cultures. All presented values indicate FDR < 0.05 with an average CPM > 1, while - - notes a values with either FDR > 0.05 or an average CPM < 1