Table 2 Differential gene expression (fold change) of immune-associated genes at hours 0, 2, and 8 post-LPS treatment of fibroblasts collected from Holstein animals as compared to fibroblasts collected from Angus animals

Innate immune related genes

CCL2

- -

- -

2.9

CCL5

- -

- -

5.7

CCL20

- -

- -

8.6

CCL26

- -

2.8

3.6

CX3CL1

- -

- -

14.8

CXCL12

−5.7

−7.4

−6.5

CXCL16

- -

- -

2.3

CXCR4

−3.1

- -

- -

HMGB1

−1.9

−1.9

−1.8

IFIH1

- -

- -

3.6

IL1R1

- -

1.5

- -

IL8

- -

- -

4.5

IRF5

2.4

2.4

2.6

MX2

- -

- -

14.0

NOD1

- -

2.4

- -

TLR2

−3.5

−2.8

- -

TLR4

3.0

4.0

2.5

TLR6

1.8

- -

2.5

TNF

- -

6.9

- -

TNFSF18

6.5

6.0

5.1

TNFSF4

4.4

- -

2.6

TRAF1

2.4

2.4

- -

TRAIP

- -

−2.7

- -

DNA Methylation associated genes

DNMT1

−1.6

−1.5

−1.5

DNMT3A

- -

- -

- -

DNMT3B

- -

- -

- -

UHRF1

−2.3

−2.0

−2.0