Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans

Table 1 Metabolites differentially produced under ionic liquid stimuli

m/z	Choline	[C₂mim]Cl	Molecular formula	Compound identification	Reference
123.0450	^a	✓	C7H8O2	orcinol	[34, 35]
151.0402		✓	C8H8O3	phenoxyacetic acid	[36]
153.0195	✓		C7H6O4	2,5-dihydroxybenzoic acid (gentisic acid)	[38, 39]
167.0348	✓^{b, c}	✓ ^{b, c}	C8H8O4	orsellinic acid	[37, 39]
179.0352	✓	✓	C9H8O4	3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid)	[39]
287.0566	✓^c		C15H12O6	monodictyphenone	[14]

UHPLC-ESI-HRMS differential analyses of putative compounds (ion masses) detected in the metabolite extracts of either choline or 1-ethyl-3-methylimidazolium chloride ([C₂mim]Cl) supplemented media, compared to the control. Compound identifications were validated by the corresponding standards
^aa compound reported equal m/z value but was not validated as orcinol;^b vestigial amounts also found in the control; ^calso detected in early time-points: monodictyphenone was detected after 5 and 10 days of incubation in choline media; and orsellinic acid was detected after 5 days of incubation in choline media and after 10 days of incubation in [C₂mim]Cl media

ISSN: 1471-2164