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Table 2 Genes of stress response differentially expressed after ionic liquid stimuli

From: Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans

  

Transcriptional profile*

 

GeneID

Gene

Choline

[C2mim]Cl

Description

AN7697

sskA

1.81

1.49

response regulator

AN0931

pbsB

−1.67

1.30

HOG signaling pathway MAPKK

AN1017

hogA

−1.73

1.01

osmotic stress-activated kinase

AN8637

catA

−2.32

1.94

catalase A

AN9339

catB

2.66

1.21

catalase B

AN5918

catC

2.34

−4.09

catalase C

AN7388

cpeA

2.76

−2.79

catalase D, catalase-peroxidase

AN5523

tpsA

−1.85

1.37

trehalose-6-phosphate synthase subunit 1

AN3441

orlA

−1.74

2.62

trehalose-6-phosphate phosphatase

AN5635

treB

1.39

2.34

neutral trehalase

AN6792

gfdB

−3.56

2.69

glycerol-3-phosphate dehydrogenase

AN5563

gldB

−1.28

2.74

NADP(+)-dependent glycerol dehydrogenase

Glutathione metabolism

AN2846

gpxA

1.23

−2.65

glutathione peroxidase

AN4905

gstA

−2.04

−1.29

theta class glutathione S-transferase

AN3299

 

3.58

2.11

glutathione S-transferase

AN6158

 

1.89

3.15

glutathione S-transferase

AN10444

ggtA

2.30

1.48

gamma-glutamyltranspeptidase

AN5658

 

2.58

−1.93

gamma-glutamyltranspeptidase

AN3459

 

1.98

−2.09

glutamate carboxypeptidase

AN2514

 

−1.16

2.81

gamma-cysteine synthetase regulatory subunit

Multidrug transporters

AN0015

 

2.01

1.68

ABC multidrug transporter

AN2349

 

−4.55

1.02

ABC multidrug transporter

AN6443

 

2.14

−1.28

ABC multidrug transporter

AN8150

 

1.48

3.80

ABC multidrug transporter

AN8489

 

7.89

−1.64

ABC multidrug transporter

AN8892

 

2.10

73.69

ABC multidrug transporter

AN9342

 

2.11

2.60

ABC multidrug transporter

AN0732

 

4.78

2.94

MFS multidrug transporter

AN1243

 

1.03

2.17

MFS multidrug transporter

AN1691

 

1.04

2.19

MFS multidrug transporter

AN2531

 

−3.69

2.22

MFS multidrug transporter

AN3301

 

1.36

7.78

MFS multidrug transporter

AN6477

 

6.42

1.48

MFS multidrug transporter

AN6942

 

8.86

77.17

MFS multidrug transporter

AN7295

 

3.12

1.25

MFS multidrug transporter

AN7466

 

1.62

2.52

MFS multidrug transporter

AN8089

 

3.70

−1.47

MFS multidrug transporter

AN8610

 

3.04

1.05

MFS multidrug transporter

AN8621

 

−5.58

2.92

MFS multidrug transporter

Autolysis/autophagy

AN0472

engA

−3.46

−3.39

β-1,3-endoglucanase

AN4871

chiB

−2.41

−5.07

chitinase B

AN1760

 

−1.81

1.28

autophagy protein Apg12

AN3734

 

−1.69

−1.26

autophagy protein Apg9

AN5876

 

−1.94

−1.30

autophagy protein Atg22

AN6360

 

1.01

1.50

autophagy protein, ATG17 homolog

AN10213

 

2.00

4.30

autophagy protein Apg6

  1. Microarray analyses (fold-change, FC) in choline or 1-ethyl-3-methylimidazolium chloride ([C2mim]Cl) supplemented media in pair-wise comparisons with the control. Values highlighted in bold are statistically significant (|FC| ≥ 1.5 and p-value ≤ 0.05)
  2. *values highlighted in bold have |FC| ≥ 1.5 and p-value ≤ 0.05 in the microarray data