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Fig. 3 | BMC Genomics

Fig. 3

From: Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases

Fig. 3

Gene length and number of splice variants are also decoupled in their linkage to the gene involvement in cancer pathways. a presents the Ltr (longest transcript length) of the genes via a 3000-nt window binning and shows the increase of the fraction of genes appearing in cancer pathways as Ltr increases. b The zoomed region below 1.6-mln-nt length for Ltr. c shows the increase of the fraction of genes appearing in cancer pathways as the Ntr number of transcripts increase. The number of genes that have a given Ntr is shown on top of each bar. d The zoomed region below 6 for Ntr, where more than 500 unique genes form each bar. e, f Density plots showing the density kernel estimates for the genes in other (e) and cancer (f) pathways respectively, calculated from the number of genes spread across varying Ltr (y-axes) and Ntr (x-axes). Please note, that the colour only denotes the density of the points, and, there is actually a positive correlation between Ltr and Ntr when taking the average values of Ltr [12] for each Ntr value. The red asterisks show the Ltr intervals where the positive Ntr shift in cancer vs. other pathways is significant. The blue asterisks show the Ntr values where the positive Ltr shift in cancer vs. other pathways is significant. For further details, see Figures S2 and S3 in Additional file 1

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