Fig. 2

The human 4TM Transporter class. The figure shows the 66 proteins of the Transporter class that are further categorized into seven different subclasses. The Transporter Classification number (TC) is determined by the Transporter Classification Database, which has been cross-referenced through Uniprot to obtain the TC number associated with the protein. The TC system is specific for membrane transport proteins and includes both functional and phylogenetic information in the numbering information. The transporter proteins identified as drug targets and the drug indications are also presented. An updated dataset of all current targeted and potential proteins and genes involved in drug studies or experimentation was used to identify proteins that are drug targets as well as the drug indications. In addition, the top common gene-disease associations are displayed for each subgroup, with the number of proteins involved in parenthesis. Three different resources were used to identify gene-disease associations: the Online Mendelian Inheritance in Man (OMIM) database; the Functional Disease Ontology (FunDO) resource; and the Jensen Lab Diseases database (see Methods for details). Proteins that participate in transport activity but do not have an associated TC number are not included in this class, but rather in a subgroup of the Miscellaneous proteins. The number in parenthesis represents the number of proteins that have been identified in that group