Fig. 4

Proteins identified in the Dual functions class. The figure shows the 47 proteins identified as having specific dual functions. All of the neurotransmitter gated ion channel (NGIC) proteins are presented here, which include 46 members that are characterized by being a transporter and having a TC number (1.A.-.-.-; alpha-type channel) as well as being identified as a receptor. The NGIC are divided into their five different protein families, and the number of proteins identified as drug targets and the drug indications are presented. In addition, one protein is determined to be both an enzyme and transporter and the information is presented in the bottom row of the figure. The drug target and drug indications were identified through an updated dataset of all current targeted and potential proteins and genes involved in drug studies or experimentation. The gene-disease associations for all NGIC proteins are also displayed. Three different resources were used to identify gene-disease associations: the Online Mendelian Inheritance in Man (OMIM) database; the Functional Disease Ontology (FunDO) resource; and the Jensen Lab Diseases database (see Methods for details). The number in parenthesis represents the number of proteins that have been identified