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Table 4 Genome-wide association of ITPR1 transcript levels

From: GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans

SNPa Geneb Chr Coordinates NCBI36 (bp) MGAc (p-value) JLAd (p-value) Effect sizee (%) Minor allele MAFf
rs877850 Intergenic 1 216328255 2.35 × 10−7 9.05 × 10−7 2.61 G 0.12
rs9311419 ITPR1 3 4855671 9.12 × 10−7 3.37 × 10−6 2.58 T 0.14
rs4685832 ITPR1 3 4859817 1.19 × 10−6 4.37 × 10−6 2.50 G 0.16
rs12581731 SCN8A 12 50311004 2.54 × 10−6 8.89 × 10−6 1.97 A 0.12
rs3805034 ITPR1 3 4855266 4.22 × 10−6 1.48 × 10−6 2.31 A 0.12
rs3805035 ITPR1 3 4855300 4.94 × 10−6 1.72 × 10−6 2.30 T 0.13
rs10886848 Intergenic 10 122831260 1.41 × 10−5 3.44 × 10−5 1.73 A 0.46
rs10170245 LOC105373893 2 220897407 1.61 × 10−5 5.36 × 10−5 1.67 A 0.09
rs4561600 Intergenic 2 142915296 1.71 × 10−5 5.70 × 10−5 1.58 G 0.17
rs4553758 Intergenic 2 142914017 1.83 × 10−5 6.07 × 10−5 1.50 A 0.21
  1. aSNP: Single nucleotide polymorphism; b ITPR1: inositol 1,4,5-trisphosphate receptor, type 1; SCN8A: sodium channel, voltage gated, type VIII alpha subunit; cMGA: Measured Genotype Analysis; dJLA: Joint Linkage Association Analysis; eEffect size: Proportion of the residual phenotypic variance that is explained by the minor allele of the SNP; fMAF: Minor Allele Frequency