Fig. 4

Molecular changes in the hypothalami of 21-day old female F1 progeny undernourished (LUN) from birth to weaning at 21 days of age. a Hierarchical clustering of transcriptional profiles, displayed as a heat map of normalized intensity values, from the hypothalamus of control (CON) and LUN mice. Each line represent individual animal. b Genes showing differential expression (DEG) classified into 25 Top Canonical Pathways by Ingenuity Pathway Analysis (IPA). The X-axis represents score for the likelihood (−log (Benjamin-Hochberg p-value < 0.05)) that genes belonging to a specific functional category are affected in the specific comparisons. The significance cutoff is shown as an orange horizontal line. Ratios (number of affected genes in a given pathway, divided by the total number of genes that make up that pathway) are shown as orange points within the bar. Ratio values are shown on the right y axis