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Fig. 4 | BMC Genomics

Fig. 4

From: Transcriptome analysis of highly purified mouse spermatogenic cell populations: gene expression signatures switch from meiotic-to postmeiotic-related processes at pachytene stage

Fig. 4

Enriched GO categories and differential expression of genes in early meiotic prophase (LZ). a. Enrichment analysis of biological process GO terms of up-regulated genes in 2C/LZ comparison. The fold enrichment shows the ratio of observed vs expected genes for each category, with an adjusted p-value <0.01. b. Venn diagram showing separate and overlapping expression between comparisons of the lists “2C/LZ up” (i.e. genes that are up-regulated in LZ compared to 2C) and “LZ/PS down” (i.e. genes that are down-regulated in PS compared to LZ). The intersection contains a subset of DEG whose expression peaks in early meiotic prophase. c. Graphical representation of the expression levels (RPKM) of the genes within the LZ peak in the four cell populations. The fifteen top genes are listed to the right in decreasing order according to their expression levels in LZ. d. Heat maps showing relative expression levels of the genes contained within GO categories “reciprocal meiotic recombination” (GO# 0007131) and “meiotic chromosome segregation” (GO# 0045132). High expression levels are indicated in red and low expression levels in green

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