Table 2 Selected categories and genes down-regulated by cAMP elevation in astrocytes
General category | ||||||
GO category | NES | FDR q-value | Gene | ID | Protein name | FC |
Cell cycle and apoptosis | ||||||
Mitosis | −1,71 | 0.018 | Ccna2 | 12428 | cyclin A2 | - 4,2 |
DNA directed DNA polymerase activity | −1,76 | 0.012 | Pold1 | 18971 | polymerase (DNA directed), delta 1, catalytic subunit | −2,3 |
Cytokinesis | −1,69 | 0.02 | Myh10 | 77579 | myosin, heavy polypeptide 10, non-muscle | −3,7 |
Cell signalling | ||||||
Ras protein signal transduction | −1,77 | 0.012 | Igf1 | 16000 | insulin-like growth factor 1 | −6.1 |
Neuropeptide hormone activity | −1,29 | 0.183 | Npy | 109648 | neuropeptide Y | - 3,5 |
Cytoskeleton, cell shape and motility | ||||||
Collagen | −1,75 | 0.013 | Col5a2 | 12832 | collagen type V a2 | - 6,7 |
Structural constituent of cytoskeleton | −1,67 | 0.023 | Tpm1 | 22003 | tropomyosin 1, alpha | −3.1 |
Cell development | ||||||
Cell development | −1,85 | 0.008 | Igfbp3 | 16009 | insulin-like growth factor binding protein 3 | - 4,1 |
Cellular metabolism | ||||||
Proteoglycan metabolic process | −1,76 | 0.012 | Chst7 | 60322 | chondroitin 6-sulfotransferase 7 | - 2,9 |
Immune response | ||||||
Inflammatory response | −1,82 | 0.01 | Ccl2 | 20296 | chemokine (C-C motif) ligand 2 | - 2,1 |
Cxcl10 | 15945 | chemokine (C-X-C motif) ligand 10 | −3,7 | |||
Others | ||||||
Lipid raft | −2,01 | 0.0088 | Cav1 | 12389 | caveolin 1 | - 4,0 |