Insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling

BMC Genomics

Table 2 Characteristics of reconstructed models from different strains and species

Organism	Model name	Number of genes in model	Number of GPRs ∗^a	Enzymatic reactions ∗^b	Transport reactions ∗^b	Spontaneous reactions ∗^c	Total number of reactions ∗^d
MHP_232	iMF170	170	233	208	111	9	426
MHP_168	iMF172a	172	234	209	111	9	427
MHP_168L	iMF172b	172	234	209	111	9	427
MHP_7422	iMF168	168	234	209	111	9	427
MHP_7448	iMF171	171	234	209	111	9	427
MHP_J	iMF172c	172	234	209	111	9	427
MHP	iMFmhp	NA ∗^e	234	209	111	9	427
MHR_HUB1	iMF177	177	239	209	111	6	423
MHR_GDL1	iMF175	175	242	210	113	6	426
MHR_SK76	iMF181	181	243	211	113	6	427
MHR_17981	iMF182	182	243	211	113	6	427
MHR	iMFmhr	NA ∗^e	243	211	113	6	427
MFL_27399	iMF159	159	217	196	105	9	401
MFL_27716	iMF157	157	217	196	105	9	401
MFL	iMFmfl	NA ∗^e	217	196	105	9	401
Pan-Network	iMFpan	NA ∗^e	258	230	117	9	457

Notes:
∗^a: GPRs are gene-proteins-reaction associations present in each genome. For iMFmhp, iMFmhr, iMFmfl and iMFpan that account for more than one species, we added a GPR to the species model when any of the strains harbored a gene responsible for a specific activity
∗^b: Reactions were considered as transport reactions even if the transporter was capable of performing a concomitant enzymatic activity
∗^c: Spontaneous reactions included diffusion of small molecules and spontaneous conversions
∗^d: Total number of reactions included also all exchange reactions needed for the mathematical modeling
∗^e: Genes in the pan-network and species models were added synthetically (one per reaction), to enable a reaction essentiality analysis

ISSN: 1471-2164