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Table 3 Genes with decreased expression in the bprR and/or bprS single mutants

From: Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

Locus tag

Gene name

Gene product/description

bprS mutant Expression (log2)

bprS mutant FDR

bprR mutant Expression (log2)

bprR mutant FDR

BPSL0153

 

putative phage protein

−1.37

8.23E-03

−0.27

4.60E-01

BPSL0154

 

phage baseplate assembly protein

−2.44

8.06E-03

−0.60

3.10E-01

BPSL0155

 

phage baseplate assembly protein

−1.65

2.96E-03

−0.87

4.55E-02

BPSL0156

 

phage baseplate assembly protein

−1.90

6.75E-04

−0.77

4.26E-02

BPSL0157

 

phage-encoded modification methylase

−2.80

8.98E-04

−1.14

3.72E-02

BPSL0159

 

phage tail completion protein

−0.90

1.70E-02

−1.72

1.33E-03

BPSL0169

 

phage terminase, endonuclease subunit

−2.26

1.02E-03

−0.94

4.27E-02

BPSL0170

 

phage major capsid protein precursor

−2.19

6.09E-03

−0.94

1.08E-01

BPSL0171

 

putative phage capsid scaffolding protein

−2.48

8.20E-03

−0.93

1.59E-01

BPSL0347

 

putative insertion element protein

−2.80

5.12E-03

−3.04

5.01E-03

BPSL0585

 

protein of unknown function

−1.69

2.38E-03

−2.18

1.04E-03

BPSL0742

 

protein of unknown function

−0.67

7.95E-02

−1.25

6.20E-03

BPSL0759

 

protein of unknown function

−1.25

9.45E-03

−0.96

2.92E-02

BPSL0761

 

protein of unknown function

−1.19

6.70E-03

−0.85

2.91E-02

BPSL1801

 

putative type-1 fimbrial protein

−1.23

4.28E-03

−1.89

2.60E-04

BPSL2112

 

hydroxydechloroatrazine ethylaminohydrolase

−1.47

4.03E-02

−2.16

7.22E-03

BPSL2113

 

putative purine catabolism-related protein

−1.41

7.63E-03

−2.33

7.13E-04

BPSL2114

 

protein of unknown function

−1.48

5.36E-03

−2.26

3.27E-04

BPSL2115

 

ureidoglycolate hydrolase

−1.13

1.61E-02

−1.69

2.22E-03

BPSL2116

 

allantoicase

−1.30

8.28E-03

−1.84

9.39E-04

BPSL2117

 

putative uricase

−1.04

3.97E-02

−1.73

3.81E-03

BPSL2118

 

protein of unknown function

−1.18

9.24E-03

−1.83

6.37E-04

BPSL2508

 

protein of unknown function

−1.48

6.03E-03

−1.07

2.36E-02

BPSL2708

 

putative exported metallo-beta-lactamase-family protein

−1.08

6.27E-04

−0.59

1.62E-02

BPSL2972

 

IclR family regulatory protein

−1.02

2.38E-03

−0.82

8.20E-03

BPSL3171

 

protein of unknown function

−1.25

6.57E-03

−0.92

2.71E-02

BPSS0063

dctD

C4-dicarboxylate transport transcriptional response regulator

−1.21

3.44E-03

−0.95

1.32E-02

BPSS0070

 

IS30 transposase

−0.66

4.42E-02

−1.06

6.19E-03

BPSS0169

 

protein of unknown function

−1.72

7.67E-03

−1.44

1.90E-02

BPSS0515

 

type VI secretion-associated protein, ImpA family

−1.86

2.63E-03

−1.75

5.74E-03

BPSS0516

 

type VI secretion protein

−1.79

8.28E-03

−1.98

9.46E-03

BPSS0517

EvpB

protein of unknown function

−2.03

1.85E-04

−1.76

5.84E-04

BPSS0518

 

type VI secretion protein

−1.98

5.17E-04

−1.74

1.41E-03

BPSS0520

 

type VI secretion protein

−1.36

9.44E-04

−1.27

2.01E-03

BPSS1034

 

protein of unknown function

−1.12

7.89E-03

−1.69

8.11E-04

BPSS1035

 

protein of unknown function

−1.74

5.66E-03

−2.24

2.78E-03

BPSS1080

 

bacteriophage baseplate assembly protein J

−1.47

8.24E-03

−0.54

1.90E-01

BPSS1085

 

bacteriophage major tail tube protein

−1.47

7.30E-03

−0.75

8.02E-02

BPSS1588

 

protein of unknown function

−1.57

3.16E-02

−2.21

5.01E-03

BPSS1740

lipB

lipase chaperone

−0.83

3.87E-02

−1.41

5.01E-03

BPSS2136

 

Family S43 non-peptidase protein

−1.24

2.38E-03

−1.16

3.97E-03

BPSS2138

oppD

oligopeptide transport ATP-binding ABC transport protein

−1.11

9.63E-03

−1.20

9.13E-03

BPSS2296

 

transport protein

−2.21

3.62E-03

−1.87

1.14E-02

  1. Genes were identified as differentially expressed if they showed >2-fold expression change (log2 < −1.0) compared to the wild-type strain with a False Discovery Rate (FDR) of <0.01. All significant gene expression changes are shown in bold and the locus tag, gene name and description are shown in bold when significant expression changes were observed for both mutants